Xiaotao Zhang1, Linda Pang2, Shreela V Sharma3, Ruosha Li4, Alan G Nyitray5, Beatrice J Edwards6. 1. Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, USA; Department of Epidemiology, Human Genetics & Environmental Sciences, University of Texas, Health Science Center at Houston, USA. 2. General Internal Medicine, University of Texas, MD Anderson Cancer Center, USA. 3. Department of Epidemiology, Human Genetics & Environmental Sciences, University of Texas, Health Science Center at Houston, USA. 4. Department of Biostatistics and Data Science, University of Texas, Health Science Center at Houston, USA. 5. Department of Psychiatry and Behavioral Medicine, Center for AIDS Intervention Research (CAIR), Medical College of Wisconsin Cancer Center, USA. 6. Central Texas Veterans Healthcare System, USA. Electronic address: Beatrice.Edwards@va.gov.
Abstract
BACKGROUND & AIMS: In this study, we assessed the prevalence of malnutrition and its association with overall survival among patients with cancer aged 65 years and older. METHODS: In this retrospective cohort study, patients receiving cancer care underwent a comprehensive geriatric assessment (CGA). Malnutrition status was determined through the CGA. We used univariate and multivariable Cox regression survival analyses to assess the association between baseline malnutrition and survival. RESULTS: A total of 454 patients with cancers were included in the analysis. The median age was 78 years and men and women were equally represented. Forty-two percent (n = 190) were malnourished at baseline, and 33% died during the follow-up (range 0.2-51.1 month). Univariate analysis showed that malnutrition increased the risk of all-cause mortality in older patients with cancer (HR, 1.49; 95% CI, 1.08-2.05; p = 0.01). In the multivariate Cox regression model, malnutrition increased the risk of all-cause mortality (HR, 1.87; 95% CI, 1.10-3.17; p = 0.02) in older patients with solid tumors. However, malnutrition did not increase the risk of all-cause mortality for hematologic malignancies. CONCLUSIONS: In our study, we found that malnutrition was a risk factor for mortality in older cancer patients, especially in older patients with solid tumors. Prospective inter ventional studies are recommended.
BACKGROUND & AIMS: In this study, we assessed the prevalence of malnutrition and its association with overall survival among patients with cancer aged 65 years and older. METHODS: In this retrospective cohort study, patients receiving cancer care underwent a comprehensive geriatric assessment (CGA). Malnutrition status was determined through the CGA. We used univariate and multivariable Cox regression survival analyses to assess the association between baseline malnutrition and survival. RESULTS: A total of 454 patients with cancers were included in the analysis. The median age was 78 years and men and women were equally represented. Forty-two percent (n = 190) were malnourished at baseline, and 33% died during the follow-up (range 0.2-51.1 month). Univariate analysis showed that malnutrition increased the risk of all-cause mortality in older patients with cancer (HR, 1.49; 95% CI, 1.08-2.05; p = 0.01). In the multivariate Cox regression model, malnutrition increased the risk of all-cause mortality (HR, 1.87; 95% CI, 1.10-3.17; p = 0.02) in older patients with solid tumors. However, malnutrition did not increase the risk of all-cause mortality for hematologic malignancies. CONCLUSIONS: In our study, we found that malnutrition was a risk factor for mortality in older cancerpatients, especially in older patients with solid tumors. Prospective inter ventional studies are recommended.
Authors: Kunal C Kadakia; James T Symanowski; Aynur Aktas; Michele L Szafranski; Jonathan C Salo; Patrick L Meadors; Declan Walsh Journal: Support Care Cancer Date: 2021-10-28 Impact factor: 3.359
Authors: Bo-Young Youn; Seo-Yeon Lee; Wonje Cho; Kwang-Rok Bae; Seong-Gyu Ko; Chunhoo Cheon Journal: Int J Environ Res Public Health Date: 2022-03-31 Impact factor: 3.390