Nadia Abdo1, Emily Boyd2, Shaunte Baboumian3, Spiro P Pantazatos4, Allan Geliebter5. 1. Institute of Human Nutrition, Columbia University, 630 West 168th Street, New York, NY 10032, United States. 2. Institute of Human Nutrition, Columbia University, 630 West 168th Street, New York, NY 10032, United States. Electronic address: emilykboyd3@gmail.com. 3. Department of Psychiatry, Mount Sinai St. Luke's, and Icahn School of Medicine at Mount Sinai, 440 West 114th St. New York, NY 10025, United States. 4. Molecular Imaging and Neuropathology Division, New York State Psychiatric Institute and Department of Psychiatry at Columbia University Irvine Medical Center, 1051 Riverside Dr, New York, NY 10032, United States. Electronic address: spiropan@gmail.com. 5. Department of Psychiatry, Mount Sinai St. Luke's, and Icahn School of Medicine at Mount Sinai, 440 West 114th St. New York, NY 10025, United States; Touro College and University System, 320 West 31st Street New York, NY 10001, United States.
Abstract
BACKGROUND: Binge eating disorder (BED) is the most prevalent eating disorder. We examined the presence of binge eating (BE) and three associated eating behaviors in relation to subcortical regional volumes and cortical thickness from brain scans. METHODS: We processed structural MRI brain scans for 466 individuals from the Nathan Kline Institute Rockland Sample using Freesurfer. We investigated subcortical volumes and cortical thicknesses among those with and without BE and in relation to the scores on dietary restraint, disinhibition, and hunger from the Three-Factor Eating Questionnaire (TFEQ). We conducted a whole-brain analysis and a region of analysis (ROI) using a priori regions associated with BE and with the three eating factors. We also compared scores on the three TFEQ factors for the BE and non-BE. RESULTS: The BE group had higher scores for dietary restraint (p = .013), disinhibition (p = 1.22E-07), and hunger (p = 5.88E-07). In the whole-brain analysis, no regions survived correction for multiple comparisons (FDR corrected p<0.01) for either BE group or interaction with TFEQ. However, disinhibition scores correlated positively with left nucleus accumbens (NAc) volume (p < 0.01 FDR corrected). In the ROI analysis, those with BE also had greater left NAc volume (p = 0.008, uncorrected) compared to non-BE. LIMITATIONS: Limitations include potential self-report bias on the EDE-Q and TFEQ. CONCLUSIONS: The findings show that BE and disinhibition scores were each associated with greater volumes in the left NAc, a reward area, consistent with a greater drive and pleasure for food.
BACKGROUND: Binge eating disorder (BED) is the most prevalent eating disorder. We examined the presence of binge eating (BE) and three associated eating behaviors in relation to subcortical regional volumes and cortical thickness from brain scans. METHODS: We processed structural MRI brain scans for 466 individuals from the Nathan Kline Institute Rockland Sample using Freesurfer. We investigated subcortical volumes and cortical thicknesses among those with and without BE and in relation to the scores on dietary restraint, disinhibition, and hunger from the Three-Factor Eating Questionnaire (TFEQ). We conducted a whole-brain analysis and a region of analysis (ROI) using a priori regions associated with BE and with the three eating factors. We also compared scores on the three TFEQ factors for the BE and non-BE. RESULTS: The BE group had higher scores for dietary restraint (p = .013), disinhibition (p = 1.22E-07), and hunger (p = 5.88E-07). In the whole-brain analysis, no regions survived correction for multiple comparisons (FDR corrected p<0.01) for either BE group or interaction with TFEQ. However, disinhibition scores correlated positively with left nucleus accumbens (NAc) volume (p < 0.01 FDR corrected). In the ROI analysis, those with BE also had greater left NAc volume (p = 0.008, uncorrected) compared to non-BE. LIMITATIONS: Limitations include potential self-report bias on the EDE-Q and TFEQ. CONCLUSIONS: The findings show that BE and disinhibition scores were each associated with greater volumes in the left NAc, a reward area, consistent with a greater drive and pleasure for food.
Authors: Rahul S Desikan; Florent Ségonne; Bruce Fischl; Brian T Quinn; Bradford C Dickerson; Deborah Blacker; Randy L Buckner; Anders M Dale; R Paul Maguire; Bradley T Hyman; Marilyn S Albert; Ronald J Killiany Journal: Neuroimage Date: 2006-03-10 Impact factor: 6.556
Authors: Gene-Jack Wang; Allan Geliebter; Nora D Volkow; Frank W Telang; Jean Logan; Millard C Jayne; Kochavi Galanti; Peter A Selig; Hao Han; Wei Zhu; Christopher T Wong; Joanna S Fowler Journal: Obesity (Silver Spring) Date: 2011-02-24 Impact factor: 5.002
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