Suzie Ferrie1,2, Amy Webster1, Betty Wu3, Charis Tan2, Sharon Carey4,5. 1. University of Sydney, Sydney, NSW, Australia. 2. Royal Prince Alfred Hospital, Sydney, NSW, Australia. 3. St George Hospital, Sydney, NSW, Australia. 4. University of Sydney, Sydney, NSW, Australia. sharon.carey1@health.nsw.gov.au. 5. Royal Prince Alfred Hospital, Sydney, NSW, Australia. sharon.carey1@health.nsw.gov.au.
Abstract
BACKGROUND/ OBJECTIVES: The impact of gastrointestinal surgery on the profile of the human gut microbiome is not fully understood. This review aimed to identify whether there is a change to the profile of the gut microbiome as a result of gastrointestinal surgery. SUBJECTS/ METHODS: In August 2018, a systematic literature search was conducted in Medline, PreMedline, Embase, CINAHL and The Cochrane Register of Clinical Trials, identifying and critically appraising studies which investigated changes to gut microbiome pre- and post-gastrointestinal surgery. RESULTS: Of 2512 results, 14 studies were included for analysis. All studies reported post-surgical change to the microbiome. In 9 of the 14 studies, prevalence of specific bacteria had significantly changed after surgery. Improved outcome was associated with higher levels of beneficial bacteria and greater microbiome diversity post-surgery. CONCLUSION: There were methodological limitations in the included studies leading to uncertainty regarding the impact of gastrointestinal surgery alone on the microbiome profile. An ideal future model for research should encompass case-controlled or cohort design with longer term follow-up in a homogeneous patient group. Future research should seek to clarify the gold standard testing method and standardised timing for post-surgical microbiome sample collection. It is imperative that controls for confounders be put in place to attempt to identify the true association between gastrointestinal surgery and changes to gut microbiome.
BACKGROUND/ OBJECTIVES: The impact of gastrointestinal surgery on the profile of the humangut microbiome is not fully understood. This review aimed to identify whether there is a change to the profile of the gut microbiome as a result of gastrointestinal surgery. SUBJECTS/ METHODS: In August 2018, a systematic literature search was conducted in Medline, PreMedline, Embase, CINAHL and The Cochrane Register of Clinical Trials, identifying and critically appraising studies which investigated changes to gut microbiome pre- and post-gastrointestinal surgery. RESULTS: Of 2512 results, 14 studies were included for analysis. All studies reported post-surgical change to the microbiome. In 9 of the 14 studies, prevalence of specific bacteria had significantly changed after surgery. Improved outcome was associated with higher levels of beneficial bacteria and greater microbiome diversity post-surgery. CONCLUSION: There were methodological limitations in the included studies leading to uncertainty regarding the impact of gastrointestinal surgery alone on the microbiome profile. An ideal future model for research should encompass case-controlled or cohort design with longer term follow-up in a homogeneous patient group. Future research should seek to clarify the gold standard testing method and standardised timing for post-surgical microbiome sample collection. It is imperative that controls for confounders be put in place to attempt to identify the true association between gastrointestinal surgery and changes to gut microbiome.
Authors: Fredrik Bäckhed; Claire M Fraser; Yehuda Ringel; Mary Ellen Sanders; R Balfour Sartor; Philip M Sherman; James Versalovic; Vincent Young; B Brett Finlay Journal: Cell Host Microbe Date: 2012-11-15 Impact factor: 21.023
Authors: Rasnik K Singh; Hsin-Wen Chang; Di Yan; Kristina M Lee; Derya Ucmak; Kirsten Wong; Michael Abrouk; Benjamin Farahnik; Mio Nakamura; Tian Hao Zhu; Tina Bhutani; Wilson Liao Journal: J Transl Med Date: 2017-04-08 Impact factor: 5.531