Literature DB >> 32661141

Metabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses.

Maria Smith1,2, Rebekah Honce2,3, Stacey Schultz-Cherry4.   

Abstract

Metabolic syndrome increases the risk of severe disease due to viral infection. Yet few studies have assessed the pathogenesis of respiratory viruses in high-risk populations. Here, we summarize how metabolic dysregulation impairs immune responses, and we define the role of metabolism during influenza virus and coronavirus infections. We also discuss the use of various in vitro, in vivo, and ex vivo models to elucidate the contributions of host factors to viral susceptibility, immunity, and disease severity.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  COVID-19; SARS-CoV-2; diabetes; influenza; metabolic syndrome; models of metabolic syndrome; obesity; type 2 diabetes mellitus; viral pathogenesis

Mesh：

Substances：

Year:  2020        PMID： 32661141      PMCID： PMC7459568          DOI： 10.1128/JVI.00665-20

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  22 in total

Review 1.  A comprehensive definition for metabolic syndrome.

Authors:  Paul L Huang
Journal:  Dis Model Mech       Date:  2009 May-Jun       Impact factor: 5.758

2.  Increased susceptibility of diabetic mice to influenza virus infection: compromise of collectin-mediated host defense of the lung by glucose?

Authors:  P C Reading; J Allison; E C Crouch; E M Anders
Journal:  J Virol       Date:  1998-08       Impact factor: 5.103

3.  Obesity Outweighs Protection Conferred by Adjuvanted Influenza Vaccination.

Authors:  Erik A Karlsson; Tomer Hertz; Cydney Johnson; Andrew Mehle; Florian Krammer; Stacey Schultz-Cherry
Journal:  MBio       Date:  2016-08-02       Impact factor: 7.867

4.  Increased risk of influenza among vaccinated adults who are obese.

Authors:  S D Neidich; W D Green; J Rebeles; E A Karlsson; S Schultz-Cherry; T L Noah; S Chakladar; M G Hudgens; S S Weir; M A Beck
Journal:  Int J Obes (Lond)       Date:  2017-06-06       Impact factor: 5.095

5.  Renin-Angiotensin-Aldosterone System Blockers and the Risk of Covid-19.

Authors:  Giuseppe Mancia; Federico Rea; Monica Ludergnani; Giovanni Apolone; Giovanni Corrao
Journal:  N Engl J Med       Date:  2020-05-01       Impact factor: 91.245

6.  Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.

Authors:  Young-Il Kim; Seong-Gyu Kim; Se-Mi Kim; Eun-Ha Kim; Su-Jin Park; Kwang-Min Yu; Jae-Hyung Chang; Eun Ji Kim; Seunghun Lee; Mark Anthony B Casel; Jihye Um; Min-Suk Song; Hye Won Jeong; Van Dam Lai; Yeonjae Kim; Bum Sik Chin; Jun-Sun Park; Ki-Hyun Chung; Suan-Sin Foo; Haryoung Poo; In-Pil Mo; Ok-Jun Lee; Richard J Webby; Jae U Jung; Young Ki Choi
Journal:  Cell Host Microbe       Date:  2020-04-06       Impact factor: 21.023

7.  Diabetes is a risk factor for the progression and prognosis of COVID-19.

Authors:  Weina Guo; Mingyue Li; Yalan Dong; Haifeng Zhou; Zili Zhang; Chunxia Tian; Renjie Qin; Haijun Wang; Yin Shen; Keye Du; Lei Zhao; Heng Fan; Shanshan Luo; Desheng Hu
Journal:  Diabetes Metab Res Rev       Date:  2020-03-31       Impact factor: 4.876

8.  Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 - United States, February 12-March 28, 2020.

Authors: 
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2020-04-03       Impact factor: 17.586

Review 9.  Diabetes in COVID-19: Prevalence, pathophysiology, prognosis and practical considerations.

Authors:  Awadhesh Kumar Singh; Ritesh Gupta; Amerta Ghosh; Anoop Misra
Journal:  Diabetes Metab Syndr       Date:  2020-04-09

10.  High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation.

Authors:  Arthur Simonnet; Mikael Chetboun; Julien Poissy; Violeta Raverdy; Jerome Noulette; Alain Duhamel; Julien Labreuche; Daniel Mathieu; Francois Pattou; Merce Jourdain
Journal:  Obesity (Silver Spring)       Date:  2020-06-10       Impact factor: 9.298
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  17 in total

Review 1.  Effects of glycine on metabolic syndrome components: a review.

Authors:  M Imenshahidi; H Hossenzadeh
Journal:  J Endocrinol Invest       Date:  2022-01-11       Impact factor: 4.256

Review 2.  Controlling the Burden of COVID-19 by Manipulating Host Metabolism.

Authors:  Logan Miller; Engin Berber; Deepak Sumbria; Barry T Rouse
Journal:  Viral Immunol       Date:  2021-12-13       Impact factor: 2.257

Review 3.  Pathogenesis of pneumonia and acute lung injury.

Authors:  Matthew E Long; Rama K Mallampalli; Jeffrey C Horowitz
Journal:  Clin Sci (Lond)       Date:  2022-05-27       Impact factor: 6.876

4.  Clash of the pandemics - At least 150'000 adults in Switzerland suffer from obesity grades 2 or 3 and are thus at elevated risk for severe COVID-19.

Authors:  Kaspar Staub; Katarina L Matthes; Frank Rühli; Nicole Bender
Journal:  F1000Res       Date:  2020-12-07

Review 5.  Understanding the Co-Epidemic of Obesity and COVID-19: Current Evidence, Comparison with Previous Epidemics, Mechanisms, and Preventive and Therapeutic Perspectives.

Authors:  Maria Dalamaga; Gerasimos Socrates Christodoulatos; Irene Karampela; Natalia Vallianou; Caroline M Apovian
Journal:  Curr Obes Rep       Date:  2021-04-28

Review 6.  Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract.

Authors:  Tim Flerlage; David F Boyd; Victoria Meliopoulos; Paul G Thomas; Stacey Schultz-Cherry
Journal:  Nat Rev Microbiol       Date:  2021-04-06       Impact factor: 78.297

Review 7.  Polycystic ovary syndrome: Pathways and mechanisms for possible increased susceptibility to COVID-19.

Authors:  Ioannis Ilias; Spyridon Goulas; Lina Zabuliene
Journal:  World J Clin Cases       Date:  2021-04-26       Impact factor: 1.337

8.  Genetic and non-genetic factors affecting the expression of COVID-19-relevant genes in the large airway epithelium.

Authors:  Tuuli Lappalainen; Stephanie A Christenson; Silva Kasela; Victor E Ortega; Molly Martorella; Suresh Garudadri; Jenna Nguyen; Elizabeth Ampleford; Anu Pasanen; Srilaxmi Nerella; Kristina L Buschur; Igor Z Barjaktarevic; R Graham Barr; Eugene R Bleecker; Russell P Bowler; Alejandro P Comellas; Christopher B Cooper; David J Couper; Gerard J Criner; Jeffrey L Curtis; MeiLan K Han; Nadia N Hansel; Eric A Hoffman; Robert J Kaner; Jerry A Krishnan; Fernando J Martinez; Merry-Lynn N McDonald; Deborah A Meyers; Robert Paine; Stephen P Peters; Mario Castro; Loren C Denlinger; Serpil C Erzurum; John V Fahy; Elliot Israel; Nizar N Jarjour; Bruce D Levy; Xingnan Li; Wendy C Moore; Sally E Wenzel; Joe Zein; Charles Langelier; Prescott G Woodruff
Journal:  Genome Med       Date:  2021-04-21       Impact factor: 15.266

9.  Saliva viral load is a dynamic unifying correlate of COVID-19 severity and mortality.

Authors:  Julio Silva; Carolina Lucas; Maria Sundaram; Benjamin Israelow; Patrick Wong; Jon Klein; Maria Tokuyama; Peiwen Lu; Arvind Venkataraman; Feimei Liu; Tianyang Mao; Ji Eun Oh; Annsea Park; Arnau Casanovas-Massana; Chantal B F Vogels; Catherine M Muenker; Joseph Zell; John B Fournier; Melissa Campbell; Michael Chiorazzi; Edwin Ruiz Fuentes; Mary Petrone; Chaney C Kalinich; Isabel M Ott; Annie Watkins; Adam J Moore; Maura I Nakahata; Nathan D Grubaugh; Shelli Farhadian; Charles Dela Cruz; Albert Ko; Wade L Schulz; Aaron M Ring; Shuangge Ma; Saad Omer; Anne L Wyllie; Akiko Iwasaki
Journal:  medRxiv       Date:  2021-01-10

Review 10.  The Nature of Immune Responses to Influenza Vaccination in High-Risk Populations.

Authors:  Kristin B Wiggins; Maria A Smith; Stacey Schultz-Cherry
Journal:  Viruses       Date:  2021-06-09       Impact factor: 5.048
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