| Literature DB >> 326606 |
H Taniguchi, M Utsumi, M Hasegawa, T Kobayashi, Y Watanabe, K Murakami, M Seki, A Tsutou, H Makimura, M Sakoda, S Baba.
Abstract
In order to clarify the physiologic role of somatostatin in insulin release, rat pancreatic islets treated by somatostatin antiserum were incubated in media containing various concentrations of glucose. Insulin release from antiserum-treated islets was significantly elevated above that from nontreated ones at 3.3 and 8.3 mM glucose, while the former was not different from the latter at 16.7 mM glucose. It is suggested that somatostatin plays an important role in the regulation of insulin release in the physiologic range of glucose concentration.Entities:
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Year: 1977 PMID： 326606 DOI： 10.2337/diab.26.7.700
Source DB: PubMed Journal: Diabetes ISSN： 0012-1797 Impact factor: 9.461