Akihiro Yoshida1,2, Takao Kimura3,4,5, Katsuhiko Tsunekawa1,6,2, Osamu Araki1,6, Kazumi Ushiki1,6, Hirotaka Ishigaki1, Yoshifumi Shoho1, Itsumi Suda1,6, Suguru Hiramoto1,6, Masami Murakami1,6,2. 1. Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan. 2. Gunma University Center for Food Science and Wellness, Maebashi, Japan. 3. Department of Clinical Laboratory Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan, tkimura@gunma-u.ac.jp. 4. Clinical Laboratory Center, Gunma University Hospital, Maebashi, Japan, tkimura@gunma-u.ac.jp. 5. Gunma University Center for Food Science and Wellness, Maebashi, Japan, tkimura@gunma-u.ac.jp. 6. Clinical Laboratory Center, Gunma University Hospital, Maebashi, Japan.
Abstract
OBJECTIVE: Given the association between diabetes suppression and inhibition of diet-induced elevation in glucose and insulin, we investigated the effects of adding glucomannan to rice gruel on pre- and postprandial glucose and insulin concentrations. METHODS: A total of 25 Japanese subjects without a history of diabetes or gastrointestinal disease (all males; aged 37-60 years; body mass index 20.4-31.6) participated in this study. Subjects received a 75-g oral glucose tolerance test (75gOGTT) and rice gruel containing 0, 0.4, or 0.8% of glucomannan. Blood samples were then obtained at preload and at 30, 60, and 120 min after receiving 75 g of glucose or rice gruel with or without glucomannan. RESULTS: After the 75gOGTT, 8 subjects had normal glucose tolerance (NGT), whereas 17 showed a borderline pattern. Moreover, our data showed that greater amounts of glucomannan promoted lesser 30-min postload plasma glucose and insulin levels, with differences being larger in the borderline group than in the NGT group. CONCLUSIONS: Glucomannan dose-dependently inhibited the rice gruel-induced increase in 30-min postprandial plasma glucose and insulin levels. Furthermore, greater inhibitory effects on glucose and insulin elevation were observed in the borderline group than in the NGT group.
OBJECTIVE: Given the association between diabetes suppression and inhibition of diet-induced elevation in glucose and insulin, we investigated the effects of adding glucomannan to rice gruel on pre- and postprandial glucose and insulin concentrations. METHODS: A total of 25 Japanese subjects without a history of diabetes or gastrointestinal disease (all males; aged 37-60 years; body mass index 20.4-31.6) participated in this study. Subjects received a 75-g oral glucose tolerance test (75gOGTT) and rice gruel containing 0, 0.4, or 0.8% of glucomannan. Blood samples were then obtained at preload and at 30, 60, and 120 min after receiving 75 g of glucose or rice gruel with or without glucomannan. RESULTS: After the 75gOGTT, 8 subjects had normal glucose tolerance (NGT), whereas 17 showed a borderline pattern. Moreover, our data showed that greater amounts of glucomannan promoted lesser 30-min postload plasma glucose and insulin levels, with differences being larger in the borderline group than in the NGT group. CONCLUSIONS:Glucomannan dose-dependently inhibited the rice gruel-induced increase in 30-min postprandial plasma glucose and insulin levels. Furthermore, greater inhibitory effects on glucose and insulin elevation were observed in the borderline group than in the NGT group.