R Zheng1, J Niu1, S Wu21, T Wang1, S Wang1, M Xu1, Y Chen1, M Dai1, D Zhang1, X Yu2, X Tang3, R Hu4, Z Ye4, L Shi5, Q Su6, L Yan7, G Qin8, Q Wan9, G Chen10, Z Gao11, G Wang12, F Shen13, Z Luo14, Y Qin14, L Chen24, Y Huo16, Q Li17, Y Zhang18, C Liu19, Y Wang20, S Wu21, T Yang22, H Deng23, L Chen24, J Zhao25, Y Mu26, Y Xu29, M Li1, J Lu1, W Wang1, Z Zhao28, Y Xu29, Y Bi30, G Ning1. 1. Shanghai National Clinical Research Centre for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China. 2. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 3. First Hospital of Lanzhou University, Lanzhou, China. 4. Zhejiang Provincial Centre for Disease Control and Prevention, Zhejiang, China. 5. Affiliated Hospital of Guiyang Medical College, Guiyang, China. 6. Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. 7. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. 8. First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. 9. Affiliated Hospital of Luzhou Medical College, Luzhou, China. 10. Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. 11. Dalian Municipal Central Hospital, Dalian Medical University, Dalian, China. 12. First Hospital of Jilin University, Changchun, China. 13. First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. 14. First Affiliated Hospital of Guangxi Medical University, Nanning, China. 15. Qilu Hospital of Shandong University, Jinan, China. 16. Jiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China. 17. Second Affiliated Hospital of Harbin Medical University, Harbin, China. 18. Central Hospital of Shanghai Jiading District, Shanghai, China. 19. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China. 20. First Affiliated Hospital of Anhui Medical University, Hefei, China. 21. Karamay Municipal People's Hospital, Xinjiang, China. 22. First Affiliated Hospital of Nanjing Medical University, Nanjing, China. 23. First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 24. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 25. Shandong Provincial Hospital affiliated to Shandong University, Jinan, China. 26. Chinese People's Liberation Army General Hospital, Beijing, China. 27. Clinical Trials Centre, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. 28. Shanghai National Clinical Research Centre for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China. Electronic address: zzybrad@hotmail.com. 29. Shanghai National Clinical Research Centre for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China. Electronic address: jane.yuxu@gmail.com. 30. Shanghai National Clinical Research Centre for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China. Electronic address: byf10784@rjh.com.cn.
Abstract
AIM: The present study examined the associations between night-time sleep duration, midday napping duration and bedtime, and fasting glucose levels, and whether or not such associations are dependent on gender and age. METHODS: This study was a cross-sectional analysis of 172,901 adults aged≥40 years living in mainland China. Sleep duration was obtained by self-reports of bedtime at night, waking-up time the next morning and average napping duration at midday. Fasting plasma glucose (FPG)≥7.0mmol/L was defined as hyperglycaemia. Independent associations between night-time sleep duration, midday naptime duration and bedtime with hyperglycaemia were evaluated using regression models. RESULTS: Compared with night-time sleep durations of 6-7.9h, both short (<6h) and long (≥8h) night-time sleep durations were significantly associated with an increased risk of hyperglycaemia in women [odds ratio (OR): 1.12, 95% confidence interval (CI): 1.01-1.29 and OR: 1.14, 95% CI: 1.08-1.21, respectively], and revealed a U-shaped distribution of risk in women and no significant association in men. Long midday nap durations (≥1h) were significantly but weakly associated with hyperglycaemia (OR: 1.04, 95% CI: 1.01-1.09) compared with no napping without interactions from gender or age, whereas the association between bedtime and fasting glucose levels did vary according to gender and age. CONCLUSION: Night-time sleep duration, midday napping duration and bedtime were all independently associated with the risk of hyperglycaemia, and some of the associations between these sleep characteristics and hyperglycaemia were gender- and age-dependent.
AIM: The present study examined the associations between night-time sleep duration, midday napping duration and bedtime, and fasting glucose levels, and whether or not such associations are dependent on gender and age. METHODS: This study was a cross-sectional analysis of 172,901 adults aged≥40 years living in mainland China. Sleep duration was obtained by self-reports of bedtime at night, waking-up time the next morning and average napping duration at midday. Fasting plasma glucose (FPG)≥7.0mmol/L was defined as hyperglycaemia. Independent associations between night-time sleep duration, midday naptime duration and bedtime with hyperglycaemia were evaluated using regression models. RESULTS: Compared with night-time sleep durations of 6-7.9h, both short (<6h) and long (≥8h) night-time sleep durations were significantly associated with an increased risk of hyperglycaemia in women [odds ratio (OR): 1.12, 95% confidence interval (CI): 1.01-1.29 and OR: 1.14, 95% CI: 1.08-1.21, respectively], and revealed a U-shaped distribution of risk in women and no significant association in men. Long midday nap durations (≥1h) were significantly but weakly associated with hyperglycaemia (OR: 1.04, 95% CI: 1.01-1.09) compared with no napping without interactions from gender or age, whereas the association between bedtime and fasting glucose levels did vary according to gender and age. CONCLUSION: Night-time sleep duration, midday napping duration and bedtime were all independently associated with the risk of hyperglycaemia, and some of the associations between these sleep characteristics and hyperglycaemia were gender- and age-dependent.