| Literature DB >> 32659465 |
Camille Bouchand1, David Nguyen1, Philippe-Henri Secretan1, Fabrice Vidal1, Romain Guery2, Sylvain Auvity3, Jeremie F Cohen2, Fanny Lanternier4, Olivier Lortholary4, Salvatore Cisternino3, Joël Schlatter5.
Abstract
Systemic use of voriconazole (VCZ) might be restricted by adverse events, such as hepatotoxicity and neurotoxicity, or drug-drug interactions. Topical VCZ application to skin may help to treat local infection more effectively and limit unwanted whole-body exposure. Topical VCZ cream was stable for 90 days when refrigerated. A patient with cutaneous Fusarium solani infection on his right forearm was successfully treated with topical 1% VCZ cream after failure of oral VCZ treatment.Entities:
Keywords: Fusarium solani; Voriconazole; fungi; skin infection; stability; topical
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Year: 2020 PMID： 32659465 DOI： 10.1016/j.ijantimicag.2020.106083
Source DB: PubMed Journal: Int J Antimicrob Agents ISSN： 0924-8579 Impact factor: 5.283