Alicia Demirjian1,2,3, Cheentan Singh4, Marc Tebruegge1,5, Rachel Herbert6, Nehal Draz6, Mariyam Mirfenderesky6, Victoria Jones4, Peter Hinstridge7, Ranjika Seneviratne8, Richard Myers2, Joanna Ellis2, Shahjahan Miah2, Christopher Is Meadows9, Julia Kenny1, Alejandra Alonso1, Jennifer Handforth1, Shona Perkins10, Mark Butler11, Frances Blackburn11, Sam Douthwaite10, Deenan Pillay12,1,7, Meera Chand2,10, Maria Zambon2. 1. From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London. 2. National Infection Service, Public Health England, London. 3. Faculty of Life Sciences & Medicine, King's College London, London. 4. Department of Paediatrics and Neonatology, North Middlesex University Hospital NHS Trust, Enfield. 5. Department of Infection, Immunity & Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London. 6. Department of Microbiology, North Middlesex University Hospital NHS Trust, Enfield. 7. Department of Obstetrics and Gynaecology, North Middlesex University Hospital NHS Trust, Enfield. 8. Anaesthetic Department, North Middlesex University Hospital NHS Trust, Enfield. 9. Department of Intensive Care, Guy's and St. Thomas' NHS Foundation Trust, London. 10. Directorate of Infection, Guy's and St. Thomas' NHS Foundation Trust, London. 11. Department of General Paediatrics, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London. 12. Trust Headquarters, North Middlesex University Hospital NHS Trust, Enfield.
Abstract
BACKGROUND: To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2. METHODS: We describe the probable vertical transmission of SARS-CoV-2 in a neonate born to a mother with coronavirus disease 2019 (COVID-19). RESULTS: Following cesarean section, the neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on respiratory samples, blood, and meconium were initially negative, but positive on a nasopharyngeal aspirate on the third day of life. On day 5, the neonate developed fever and coryza, which spontaneously resolved. Viral genomic analysis from the mother and neonate showed identical sequences except for 1 nucleotide. CONCLUSION: This report has important implications for infection control and clinical management of pregnant women with COVID-19 and their newborns.
BACKGROUND: To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2. METHODS: We describe the probable vertical transmission of SARS-CoV-2 in a neonate born to a mother with coronavirus disease 2019 (COVID-19). RESULTS: Following cesarean section, the neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on respiratory samples, blood, and meconium were initially negative, but positive on a nasopharyngeal aspirate on the third day of life. On day 5, the neonate developed fever and coryza, which spontaneously resolved. Viral genomic analysis from the mother and neonate showed identical sequences except for 1 nucleotide. CONCLUSION: This report has important implications for infection control and clinical management of pregnant women with COVID-19 and their newborns.
Authors: Elyse G Mark; Samuel McAleese; W Christopher Golden; Maureen M Gilmore; Anna Sick-Samuels; Melanie S Curless; Lawrence M Nogee; Aaron M Milstone; Julia Johnson Journal: Pediatr Infect Dis J Date: 2021-05-01 Impact factor: 2.129
Authors: Gonzalo Solís-García; Ana Gutiérrez-Vélez; Isabel Pescador Chamorro; Elena Zamora-Flores; Sara Vigil-Vázquez; Elena Rodríguez-Corrales; Manuel Sánchez-Luna Journal: An Pediatr (Engl Ed) Date: 2021-01-26
Authors: Itzíar Carrasco; Mar Muñoz-Chapuli; Sara Vigil-Vázquez; David Aguilera-Alonso; Concepción Hernández; César Sánchez-Sánchez; Cristina Oliver; Mónica Riaza; Marta Pareja; Olga Sanz; Beatriz Pérez-Seoane; Juan López; Elena Márquez; Sara Domínguez-Rodríguez; Alicia Hernanz-Lobo; Juan Antonio De León-Luis; Manuel Sánchez-Luna; María Luisa Navarro Journal: BMC Pregnancy Childbirth Date: 2021-04-26 Impact factor: 3.007