Manik Kataruka1, Shefali Gupta2, Raja Ramchandran1, Mini Singh3, Radha Krishan Dhiman4, Kishan Lal Gupta1. 1. Post Graduate Institute of Medical Education and Research, Nephrology, India. 2. Institute of Liver and Biliary Science, Virology, India. 3. Post Graduate Institute of Medical Education and Research, Virology, India. 4. Post Graduate Institute of Medical Education and Research, Hepatology, India.
Abstract
BACKGROUND: Renal replacement therapy in the form of either dialysis or transplantation is the only option for end-stage renal disease (ESRD). Blood-borne infections such as hepatitis B virus (HBV) and hepatitis C virus (HCV) are of special concern in these patients because of their high incidence. Although there are sufficient data from the developed world, there is scarcity of data from developing countries such as India. METHODS: All newly diagnosed ESRD patients initiated on hemodialysis after attending the Department of Nephrology, PGIMER, Chandigarh between January 2015 and October 2015 were included in the study. All the subjects were initially screened for HCV and HBV serology status and subsequent HCV and HBV status on follow-up at the end of 6 months and evaluated by standardized precoded questionnaires and biochemical examinations. Univariate and multivariate analyses were done to identify the risk factors for seroconversion. RESULTS: A total of 196 patients were recruited for the study after confirming seronegative status. At the end of 6 months, 61 patients lost to follow-up. Anti-HCV antibody had shown moderate association to HCV RNA testing at the end of 6 months by kappa test. Out of 135, 16.3% seroconverted to HCV RNA positive and 0.7% patient became hepatitis B surface antigen positive. Isolation of dialysis machine and nursing staff was associated with lower seroconversion. CONCLUSION: In a real-life scenario, HCV seroconversion is observed in 15% of the patients initiated on hemodialysis. Isolation of both dialysis machine and personnel was associated with lower seroconversion.
BACKGROUND: Renal replacement therapy in the form of either dialysis or transplantation is the only option for end-stage renal disease (ESRD). Blood-borne infections such as hepatitis B virus (HBV) and hepatitis C virus (HCV) are of special concern in these patients because of their high incidence. Although there are sufficient data from the developed world, there is scarcity of data from developing countries such as India. METHODS: All newly diagnosed ESRD patients initiated on hemodialysis after attending the Department of Nephrology, PGIMER, Chandigarh between January 2015 and October 2015 were included in the study. All the subjects were initially screened for HCV and HBV serology status and subsequent HCV and HBV status on follow-up at the end of 6 months and evaluated by standardized precoded questionnaires and biochemical examinations. Univariate and multivariate analyses were done to identify the risk factors for seroconversion. RESULTS: A total of 196 patients were recruited for the study after confirming seronegative status. At the end of 6 months, 61 patients lost to follow-up. Anti-HCV antibody had shown moderate association to HCV RNA testing at the end of 6 months by kappa test. Out of 135, 16.3% seroconverted to HCV RNA positive and 0.7% patient became hepatitis B surface antigen positive. Isolation of dialysis machine and nursing staff was associated with lower seroconversion. CONCLUSION: In a real-life scenario, HCV seroconversion is observed in 15% of the patients initiated on hemodialysis. Isolation of both dialysis machine and personnel was associated with lower seroconversion.
Authors: S Jasuja; A K Gupta; R Choudhry; V Kher; D K Aggarwal; A Mishra; M Agarwal; A Sarin; M K Mishra; V Raina Journal: Indian J Nephrol Date: 2009-04
Authors: Rachel B Fissell; Jennifer L Bragg-Gresham; John D Woods; Michel Jadoul; Brenda Gillespie; Sara A Hedderwick; Hugh C Rayner; Roger N Greenwood; Takashi Akiba; Eric W Young Journal: Kidney Int Date: 2004-06 Impact factor: 10.612
Authors: Rachel A Burdick; Jennifer L Bragg-Gresham; John D Woods; Sara A Hedderwick; Kiyoshi Kurokawa; Christian Combe; Akira Saito; John LaBrecque; Friedrich K Port; Eric W Young Journal: Kidney Int Date: 2003-06 Impact factor: 10.612