Literature DB >> 32652879

A natural BACE1 and GSK3β dual inhibitor Notopterol effectively ameliorates the cognitive deficits in APP/PS1 Alzheimer's mice by attenuating amyloid-β and tau pathology.

Xiaowen Jiang1,2,3, Hongyuan Lu3,4, Jingda Li1,2,3, Wenwu Liu1,2,3, Qiong Wu2,4, Zihua Xu2,3, Qinglong Qiao5, Haotian Zhang4, Huiyuan Gao1,3, Qingchun Zhao1,2,3,4.   

Abstract

Entities:  

Year:  2020        PMID： 32652879      PMCID： PMC7418795          DOI： 10.1002/ctm2.50

Source DB:  PubMed          Journal:  Clin Transl Med        ISSN： 2001-1326


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  9 in total

1.  Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures.

Authors:  W-H Zheng; S Bastianetto; F Mennicken; W Ma; S Kar
Journal:  Neuroscience       Date:  2002       Impact factor: 3.590

2.  Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells.

Authors:  A C Lo; C Haass; S L Wagner; D B Teplow; S S Sisodia
Journal:  J Biol Chem       Date:  1994-12-09       Impact factor: 5.157

3.  Versatility of the Curcumin Scaffold: Discovery of Potent and Balanced Dual BACE-1 and GSK-3β Inhibitors.

Authors:  Rita Maria Concetta Di Martino; Angela De Simone; Vincenza Andrisano; Paola Bisignano; Alessandra Bisi; Silvia Gobbi; Angela Rampa; Romana Fato; Christian Bergamini; Daniel I Perez; Ana Martinez; Giovanni Bottegoni; Andrea Cavalli; Federica Belluti
Journal:  J Med Chem       Date:  2016-01-07       Impact factor: 7.446

4.  Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors.

Authors:  Federica Prati; Angela De Simone; Paola Bisignano; Andrea Armirotti; Maria Summa; Daniela Pizzirani; Rita Scarpelli; Daniel I Perez; Vincenza Andrisano; Ana Perez-Castillo; Barbara Monti; Francesca Massenzio; Letizia Polito; Marco Racchi; Angelo D Favia; Giovanni Bottegoni; Ana Martinez; Maria Laura Bolognesi; Andrea Cavalli
Journal:  Angew Chem Int Ed Engl       Date:  2014-12-11       Impact factor: 15.336

5.  Arctigenin effectively ameliorates memory impairment in Alzheimer's disease model mice targeting both β-amyloid production and clearance.

Authors:  Zhiyuan Zhu; Jianming Yan; Wei Jiang; Xin-gang Yao; Jing Chen; Lili Chen; Chenjing Li; Lihong Hu; Hualiang Jiang; Xu Shen
Journal:  J Neurosci       Date:  2013-08-07       Impact factor: 6.167

Review 6.  Dual BACE-1/GSK-3β Inhibitors to Combat Alzheimer's Disease: A Focused Review.

Authors:  Angela Rampa; Silvia Gobbi; Rita Maria Concetta Di Martino; Federica Belluti; Alessandra Bisi
Journal:  Curr Top Med Chem       Date:  2017       Impact factor: 3.295

Review 7.  Amyloid-β and tau complexity - towards improved biomarkers and targeted therapies.

Authors:  Juan Carlos Polanco; Chuanzhou Li; Liviu-Gabriel Bodea; Ramon Martinez-Marmol; Frederic A Meunier; Jürgen Götz
Journal:  Nat Rev Neurol       Date:  2017-12-15       Impact factor: 42.937

8.  Rescue of long-range circuit dysfunction in Alzheimer's disease models.

Authors:  Marc Aurel Busche; Maja Kekuš; Helmuth Adelsberger; Takahiro Noda; Hans Förstl; Israel Nelken; Arthur Konnerth
Journal:  Nat Neurosci       Date:  2015-10-12       Impact factor: 24.884

Review 9.  Toxin-Induced Experimental Models of Learning and Memory Impairment.

Authors:  Sandeep Vasant More; Hemant Kumar; Duk-Yeon Cho; Yo-Sep Yun; Dong-Kug Choi
Journal:  Int J Mol Sci       Date:  2016-09-01       Impact factor: 5.923
  9 in total
  6 in total

1.  Notopterol Attenuates Monocrotaline-Induced Pulmonary Arterial Hypertension in Rat.

Authors:  Lin Huang; Huayang Li; Suiqing Huang; Shunjun Wang; Quan Liu; Li Luo; Shuangjiao Gan; Guangguo Fu; PeiYun Zou; Guangxian Chen; Zhongkai Wu
Journal:  Front Cardiovasc Med       Date:  2022-06-03

2.  Trilobatin rescues cognitive impairment of Alzheimer's disease by targeting HMGB1 through mediating SIRT3/SOD2 signaling pathway.

Authors:  Jian-Mei Gao; Xun Zhang; Guo-Tao Shu; Na-Na Chen; Jian-Yong Zhang; Fan Xu; Fei Li; Yuan-Gui Liu; Yu Wei; Yu-Qi He; Jing-Shan Shi; Qi-Hai Gong
Journal:  Acta Pharmacol Sin       Date:  2022-03-15       Impact factor: 7.169

Review 3.  Research Progress of Natural Small-Molecule Compounds Related to Tumor Differentiation.

Authors:  Xiaoli He; Yongkang Liao; Jing Liu; Shuming Sun
Journal:  Molecules       Date:  2022-03-25       Impact factor: 4.411

4.  Yuan-Zhi decoction in the treatment of Alzheimer's disease: An integrated approach based on chemical profiling, network pharmacology, molecular docking and experimental evaluation.

Authors:  Qiong Wu; Xiang Li; Xiao-Wen Jiang; Dong Yao; Li-Jun Zhou; Zi-Hua Xu; Nan Wang; Qing-Chun Zhao; Zhou Zhang
Journal:  Front Pharmacol       Date:  2022-08-24       Impact factor: 5.988

5.  Design, Synthesis, and Biological Evaluation of Notopterol Derivatives as Triple Inhibitors of AChE/BACE1/GSK3β for the Treatment of Alzheimer's Disease.

Authors:  Nan Wang; Wenjie Liu; Lijun Zhou; Wenwu Liu; Xu Liang; Xin Liu; Zihua Xu; Tianming Zhong; Qiong Wu; Xinming Jiao; Jiangxia Chen; Xinyue Ning; Xiaowen Jiang; Qingchun Zhao
Journal:  ACS Omega       Date:  2022-08-30

Review 6.  Amyloid Cross-Seeding: Mechanism, Implication, and Inhibition.

Authors:  Sushma Subedi; Santanu Sasidharan; Niharika Nag; Prakash Saudagar; Timir Tripathi
Journal:  Molecules       Date:  2022-03-08       Impact factor: 4.411
  6 in total

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