Jeanette Therming Jørgensen1, Johnni Hansen2, Rudi G J Westendorp3,4, Kirsten Nabe-Nielsen5, Leslie Thomas Stayner6, Mette Kildevaeld Simonsen7, Zorana Jovanovic Andersen1,8. 1. Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 2. Danish Cancer Research Centre, Danish Cancer Society, Copenhagen, Denmark. 3. Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 4. Center for Healthy Aging, University of Copenhagen, Copenhagen, Denmark. 5. Section of Social Medicine, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 6. Division of Epidemiology & Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, Illinois, USA. 7. Frederiksberg Hospital, Diakonissestiftelsen and Parker Institute, Frederiksberg, Denmark. 8. Nykøbing F. Hospital, Hospitalsvej, Centre for Epidemiological Research, Nykøbing Falster, Denmark.
Abstract
INTRODUCTION: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). DISCUSSION: Persistent night shift work may increase the risk of dementia.
INTRODUCTION: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. METHODS: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. RESULTS: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). DISCUSSION: Persistent night shift work may increase the risk of dementia.
Keywords:
Alzheimer's disease and dementia; Danish Nurse Cohort; Denmark; cohort study; neurodegenerative disease; night shift work; shift work; working time
Authors: Lieve T van Egmond; Shervin Bukhari; Andrea Lessa Benedet; Nicholas J Ashton; Elisa M S Meth; Alexander Boukas; Joachim Engström; Maria Ilemosoglou; Kaj Blennow; Henrik Zetterberg; Christian Benedict Journal: Transl Psychiatry Date: 2022-09-10 Impact factor: 7.989