| Literature DB >> 32651849 |
Michael Mauer1, Alessandro Doria2.
Abstract
Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD) in the Western world. Better control of glycemia and blood pressure, including renin-angiotensin system blockade (RASB), appear to have slowed DKD progression rate but have been unable to substantially decrease the annual incidence of new cases of DKD related ESKD. Thus, new treatment targets are needed. Higher levels of serum uric acid (SUA) have been associated with increased risk and progression of DKD in persons with types 1 (T1D) and 2 (T2D) diabetes and of chronic kidney disease (CKD) in general. This review presents the epidemiological, clinical, and clinical trial evidence regarding the hypothesis that SUA reduction could slow progression of DKD and/or CKD in general.Entities:
Keywords: Diabetes; Kidney disease; Uric acid
Year: 2020 PMID: 32651849 DOI: 10.1007/s40620-020-00796-z
Source DB: PubMed Journal: J Nephrol ISSN: 1121-8428 Impact factor: 3.902