| Literature DB >> 32651014 |
Rodrigo Barquera1, Diana Iraíz Hernández-Zaragoza2, Alicia Bravo-Acevedo3, Esteban Arrieta-Bolaños4, Stephen Clayton5, Víctor Acuña-Alonzo6, Julio César Martínez-Álvarez7, Concepción López-Gil8, Carmen Adalid-Sáinz9, María Del Rosario Vega-Martínez10, Araceli Escobedo-Ruíz11, Eva Dolores Juárez-Cortés12, Alexander Immel13, Hanna Pacheco-Ubaldo6, Liliana González-Medina6, Abraham Lona-Sánchez6, Julio Lara-Riegos14, María Guadalupe de Jesús Sánchez-Fernández15, Rosario Díaz-López16, Gregorio Ulises Guizar-López16, Carolina Elizabeth Medina-Escobedo17, María Araceli Arrazola-García7, Gustavo Daniel Montiel-Hernández18, Ofelia Hernández-Hernández19, Flor Del Rocío Ramos-de la Cruz8, Francisco Juárez-Nicolás20, Jorge Arturo Pantoja-Torres21, Tirzo Jesús Rodríguez-Munguía22, Vicencio Juárez-Barreto23, Héctor Delgado-Aguirre9, Ariadna Berenice Escutia-González20, Isis Goné-Vázquez11, Gamaliel Benítez-Arvizu7, Francia Paulina Arellano-Prado24, Víctor Eduardo García-Arias24, Marla Estefanía Rodríguez-López24, Patricia Méndez-Mani8, Raquel García-Álvarez25, Marisela Del Rocío González-Martínez26, Guadalupe Aquino-Rubio22, Néstor Escareño-Montiel27, Tannya Verónica Vázquez-Castillo28, María Guadalupe Uribe-Duarte29, María de Jesús Ruíz-Corral29, Andrea Ortega-Yáñez30, Natalia Bernal-Felipe18, Benjamín Gómez-Navarro31, Agustín Jericó Arriaga-Perea12, Virginia Martínez-Bezies20, Rosa María Macías-Medrano12, Jesús Abraham Aguilar-Campos29, Raúl Solís-Martínez28, Ricardo Serrano-Osuna29, Mario J Sandoval-Sandoval32, Yolanda Jaramillo-Rodríguez33, Antonio Salgado-Adame33, Federico Juárez-de la Cruz27, Bárbara Novelo-Garza34, María de Los Ángeles Pavón-Vargas8, Norma Salgado-Galicia10, Maria Cátira Bortolini35, Carla Gallo36, Gabriel Bedoya37, Francisco Rothhammer38, Rolando González-José39, Andrés Ruiz-Linares40, Samuel Canizales-Quinteros41, Sandra Romero-Hidalgo42, Johannes Krause5, Joaquín Zúñiga43, Edmond J Yunis44, Carolina Bekker-Méndez45, Julio Granados46.
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) allele groups and alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states of the country divided into 78 sample sets, providing information regarding allelic and haplotypic frequencies and their linkage disequilibrium, as well as admixture estimates and genetic substructure. We identified the presence of 4268 unique HLA extended haplotypes across Mexico and find that the ten most frequent (HF > 1%) HLA haplotypes with significant linkage disequilibrium (Δ'≥0.1) in Mexico (accounting for 20% of the haplotypic diversity of the country) are of primarily Native American ancestry (A*02~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*08~DQB1*04, A*68~B*39~DRB1*04~DQB1*03:02, A*02~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*14~DQB1*03:01, A*24~B*35~DRB1*04~DQB1*03:02, A*24~B*39~DRB1*04~DQB1*03:02, A*02~B*40:02~DRB1*04~DQB1*03:02, A*68~B*35~DRB1*04~DQB1*03:02, A*02~B*15:01~DRB1*04~DQB1*03:02). Admixture estimates obtained by a maximum likelihood method using HLA-A/-B/-DRB1 as genetic estimators revealed that the main genetic components in Mexico as a whole are Native American (ranging from 37.8% in the northern part of the country to 81.5% in the southeastern region) and European (ranging from 11.5% in the southeast to 62.6% in northern Mexico). African admixture ranged from 0.0 to 12.7% not following any specific pattern. We were able to detect three major immunogenetic clusters correlating with genetic diversity and differential admixture within Mexico: North, Central and Southeast, which is in accordance with previous reports using genome-wide data. Our findings provide insights into the population immunogenetic substructure of the whole country and add to the knowledge of mixed ancestry Latin American population genetics, important for disease association studies, detection of demographic signatures on population variation and improved allocation of public health resources.Entities:
Keywords: Admixture; Genetic substructure; HLA; Immunogenetics; Latin American populations; Mexico; Population genetics
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Year: 2020 PMID： 32651014 DOI： 10.1016/j.humimm.2020.06.008
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850