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Literature DB >> 32647401

Novel strategies for enhancing shotgun lipidomics for comprehensive analysis of cellular lipidomes.

Changfeng Hu¹, Chunyan Wang², Lijiao He¹, Xianlin Han^1,2,3.

Abstract

Shotgun lipidomics is one of the most powerful tools in analysis of cellular lipidomes in lipidomics, which directly analyzes lipids from lipid extracts of diverse biological samples with high accuracy/precision. However, despite its great advances in high throughput analysis of cellular lipidomes, low coverage of poorly ionized lipids, especially those species in very low abundance, and some types of isomers within complex lipid extracts by shotgun lipidomics remains a huge challenge. In the past few years, many strategies have been developed to enhance shotgun lipidomics for comprehensive analysis of lipid species. Chemical derivatization represents one of the most attractive and effective strategies, already receiving considerable attention. This review focuses on novel advanced derivatization strategies for enhancing shotgun lipidomics. It is anticipated that with the development of enhanced strategies, shotgun lipidomics can make greater contributions to biological and biomedical research.

Entities: Chemical Disease Gene Species

Keywords: Bis(monoacylglycero) phosphate; chemical derivatization; multi-dimensional mass spectrometry; plasmalogen; polyphosphoinositides; shotgun lipidomics

Year: 2018 PMID： 32647401 PMCID： PMC7344273 DOI： 10.1016/j.trac.2018.11.028

Source DB: PubMed Journal: Trends Analyt Chem ISSN： 0165-9936 Impact factor: 12.296

92 in total

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Journal: Anal Chem Date: 2007-05-03 Impact factor: 6.986

4. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses.

Authors: Zeynep Akgoc; Miguel Sena-Esteves; Douglas R Martin; Xianlin Han; Alessandra d'Azzo; Thomas N Seyfried
Journal: J Lipid Res Date: 2015-03-20 Impact factor: 5.922

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Journal: J Biol Chem Date: 1998-08-07 Impact factor: 5.157

6. Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics.

Authors: Kui Yang; Hua Cheng; Richard W Gross; Xianlin Han
Journal: Anal Chem Date: 2009-06-01 Impact factor: 6.986

7. Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease.

Authors: Leanne K Hein; Stephen Duplock; Maria Fuller
Journal: J Lipid Res Date: 2013-04-06 Impact factor: 5.922

8. A phosphoinositide conversion mechanism for exit from endosomes.

Authors: Katharina Ketel; Michael Krauss; Anne-Sophie Nicot; Dmytro Puchkov; Marnix Wieffer; Rainer Müller; Devaraj Subramanian; Carsten Schultz; Jocelyn Laporte; Volker Haucke
Journal: Nature Date: 2016-01-13 Impact factor: 49.962

9. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

Authors: Mark M Yore; Ismail Syed; Pedro M Moraes-Vieira; Tejia Zhang; Mark A Herman; Edwin A Homan; Rajesh T Patel; Jennifer Lee; Shili Chen; Odile D Peroni; Abha S Dhaneshwar; Ann Hammarstedt; Ulf Smith; Timothy E McGraw; Alan Saghatelian; Barbara B Kahn
Journal: Cell Date: 2014-10-09 Impact factor: 41.582

10. A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language.

Authors: Ronny Herzog; Dominik Schwudke; Kai Schuhmann; Julio L Sampaio; Stefan R Bornstein; Michael Schroeder; Andrej Shevchenko
Journal: Genome Biol Date: 2011-01-19 Impact factor: 13.583

8 in total

Novel strategies for enhancing shotgun lipidomics for comprehensive analysis of cellular lipidomes.

Review 1. An introduction to quadrupole-time-of-flight mass spectrometry.

2. Automated identification and quantification of glycerophospholipid molecular species by multiple precursor ion scanning.

3. Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra.

4. Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses.

5. Mapping of a molecular determinant for protein kinase C betaII isozyme function.

6. Automated lipid identification and quantification by multidimensional mass spectrometry-based shotgun lipidomics.

7. Selective reduction of bis(monoacylglycero)phosphate ameliorates the storage burden in a THP-1 macrophage model of Gaucher disease.

8. A phosphoinositide conversion mechanism for exit from endosomes.

9. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects.

10. A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language.

1. Analytical challenges of shotgun lipidomics at different resolution of measurements.

Review 2. Strategies to Improve/Eliminate the Limitations in Shotgun Lipidomics.

Review 3. Tricky Isomers-The Evolution of Analytical Strategies to Characterize Plasmalogens and Plasmanyl Ether Lipids.

4. Overview of Lipidomic Analysis of Triglyceride Molecular Species in Biological Lipid Extracts.

Review 5. Towards Physiologic Culture Approaches to Improve Standard Cultivation of Mesenchymal Stem Cells.

Review 6. RECOGNITION AND AVOIDANCE OF ION SOURCE-GENERATED ARTIFACTS IN LIPIDOMICS ANALYSIS.

Review 7. Recent advances in analytical strategies for mass spectrometry-based lipidomics.

8. Recurrent Topics in Mass Spectrometry-Based Metabolomics and Lipidomics-Standardization, Coverage, and Throughput.