Synthesis of Cyclo[18]carbon via Debromination of C18Br6.

Cyclo[18]carbon (C18, a molecular carbon allotrope) can be synthesized by dehalogenation of a bromocyclocarbon precursor, C18Br6, in 64% yield, by atomic manipulation on a sodium chloride bilayer on Cu(111) at 5 K, and imaged by high-resolution atomic force microscopy. This method of generating C18 gives a higher yield than that reported previously from the cyclocarbon oxide C24O6. The experimental images of C18 were compared with simulated images for four theoretical model geometries, including possible bond-angle alternation: D18h cumulene, D9h polyyne, D9h cumulene, and C9h polyyne. Cumulenic structures, with (D9h) and without (D18h) bond-angle alternation, can be excluded. Polyynic structures, with (C9h) and without (D9h) bond-angle alternation, both show a good agreement with the experiment and are challenging to differentiate.

Synthetic carbon-rich materials and new carbon allotropes have attracted much attention over the past half century.[1] Allotropes based on two-coordinate sp-hybridized carbon are much more elusive than those based on trigonal sp2-hybridized carbon.[2] Recently, we reported the synthesis of cyclo[18]carbon, by elimination of carbon monoxide from C24O6 on bilayer sodium chloride on Cu(111) at 5 K, and we characterized this molecular carbon allotrope by high resolution atomic force microscopy (AFM).[18]carbon. Science. 2019 ">3] Molecules of C18 showed a 9-fold symmetry, indicating a polyyne structure. However, many questions remain unanswered about the structure and properties of cyclo[n]carbons.[18]carbon. Chem. - Eur. J.. 2020 ">4,5] Second-order Jahn–Teller effects have been proposed to cause both bond-length alternation (BLA) and bond-angle alternation (BAA) in these homoatomic rings,[4,6−9] whereas Hückel aromaticity should favor a high-symmetry structure in C rings with n = 4m + 2, such as C18.[10] Theoretical studies have suggested four possible geometries for C18: D18 cumulene, D9 polyyne, D9 cumulene, and C9 polyyne (A–D, Figure a–d).[4,6−9] Here we report a study of C18 synthesized via a new route: dehalogenation of C18Br6, which occurs under milder conditions, and in five times higher yield (64%) compared to the yield of formation from C24O6 (13%). The dissociated Br atoms are immobile on the NaCl surface under our imaging conditions and hinder motion of the C18 molecules, which facilitated high-resolution AFM imaging at different tip heights. We compared the AFM data for C18 with simulated images for structures A–D, using different bond lengths (d1 and d2) and different bond angles (θ1 and θ2). The results show that the cumulenic D18 and D9 geometries can be excluded, while both the polyyne geometries, D9 and C9, are consistent with the experimental images.

Figure 1

Possible geometries of cyclo[18]carbon, A–D, together with respective simulated AFM images at two different tip–sample distances, (e)–(h): Δz = 0.6 Å; (i)–(l): Δz = 0.2 Å. The AFM simulations correspond to geometries with A: d1 = d2 = 1.30 Å, θ1 = θ2 = 160°; B: d1 = 1.38 Å, d2 = 1.24 Å, θ1 = θ2 = 160°; C: d1 = d2 = 1.30 Å, θ1 = 171.4°, θ2 = 148.6°; D: d1 = 1.38 Å, d2 = 1.24 Å, θ1 = 173.1°, θ2 = 146.9°. The scale bar in (e) is 5 Å and applies to all simulated AFM images.

The bromocyclocarbon precursor, C18Br6, was synthesized as shown in Scheme . Syn-selective diboration of the central C≡C triple bond of bis(triisopropylsilyl)hexatriyne 1, using a platinum-catalyzed reaction developed by Suzuki et al.,[11] proceeded cleanly to give the (Z)-bis(boryl)enediyne 2. This intermediate was stereoselectively bromodeboronated using copper(II) bromide, to yield the TIPS-protected (Z)-dibromo-enediyne 3, in 53% yield over two steps, which was deprotected using tetrabutylammonium fluoride (TBAF) to yield (Z)-dibromo-enediyne 4. This enediyne is unstable in the pure form and must be handled as a solution. Oxidative cyclo-oligomerization of 4 under catalytic Glaser–Hay conditions[12] (CuCl·TMEDA, 0.2 equiv) gave C18Br6 in 4% yield over two steps as a bright red, sparingly soluble, crystalline solid. Other cyclic oligomers, C12Br4 and C24Br8, were also tentatively detected in the reaction mixture, but have not yet been isolated.

Scheme 1

Synthesis of Cyclo[18]carbon via C18Br6

C18Br6 is stable under ambient conditions, in solution, and in the solid state, with no significant decomposition over several days at room temperature, and the solid can be stored for weeks at −20 °C. However, it is a shock-sensitive explosive (e.g., it explodes when scratched with a spatula) and care was taken to work on a small scale. Differential scanning calorimetry showed that C18Br6 undergoes exothermic decomposition at 85–125 °C (ΔH = −109 kJ/mol). C18Br6 is almost insoluble in most organic solvents but sparingly soluble in carbon disulfide. Single crystals suitable for X-ray analysis were grown from a saturated solution of C18Br6 in CS2 at 4 °C (Figure ). The crystals are orthorhombic with eight molecules per unit cell, and half a molecule of C18Br6 in the asymmetric unit. The compound adopts a layer structure, with a layer spacing of 3.412(1) Å, and the packing arrangement resembles that in the corresponding hydrocarbon, C18H6.[13]

Figure 2

Crystal structure of C18Br6, viewed along the crystallographic b-axis, showing two layers of molecules. The central rectangle is the unit cell. (Thermal ellipsoids: 50% probability level.)

The synthesis and characterization of C18 was carried out in a low-temperature combined STM/AFM system (for more details, see Supporting Information). The C18Br6 precursor was thermally sublimed onto a cold Cu(111) surface (T ≈ 5 K) partially covered with NaCl bilayer islands, yielding a submonolayer coverage of well-dispersed molecules. No intact C18Br6 molecules were observed on the bare Cu(111) surface, possibly due to its high reactivity, and all atom-manipulation experiments were carried out on bilayer NaCl. The tip was functionalized with carbon monoxide (CO) to enhance the AFM contrast.[14,15] AFM measurements were recorded in constant-height mode, where Δz denotes the tip height offset with respect to the STM set point (positive Δz corresponds to an increase in tip–sample distance).

Sublimation of C18Br6 onto bilayer NaCl yielded almost exclusively intact C18Br6 molecules with no appearance of C18. A small fraction of the molecules (less than 5%) appeared to be missing one of the six Br atoms. This indicates that, unlike the cyclocarbon oxide precursor C24O6,[18]carbon. Science. 2019 ">3] no significant unmasking occurs during sublimation and adsorption. Figure a–d show AFM images of the intact C18Br6 precursor recorded at different tip–sample distances, revealing a characteristic triangular shape. The six bright features at the corners relate to the Br atoms and the bright features along the edges of the triangular core correspond to C≡C triple bonds.[18]carbon. Science. 2019 ">3,16,17] The nonuniform brightness of Br atoms and triple bonds within the molecule results from a nonplanar adsorption geometry, with the brighter parts of the molecule indicating their greater height.[18] These differences are most distinct in the AFM images recorded at large tip–sample distances (Figure a,b). At small tip–sample distances (Figure c,d), tip relaxations, such as tilting of the CO, cause image distortions, which lead to apparent sharpening of the bonds[15,19] and facilitate bond-order discrimination.[19,20]

Figure 3

AFM images of (a)–(d) C18Br6 and (e)–(h) cyclo[18]carbon recorded at different Δz. In (e)–(h), the scan angle was adjusted such that the scanned plane was parallel to the molecule instead of the underlying surface. Δz denotes the difference in tip–sample distance with respect to the set point of I = 0.5 pA, V = 0.2 V. All scale bars 5 Å.

Debromination of C18Br6 was achieved by positioning the tip at a lateral distance of 1–3 nm from the center of the molecule, retracting it by 2–3 Å from the STM set point (typically I = 0.5 pA, V = 0.2 V) to minimize the tunneling current (I < 50 fA) and increasing the bias voltage to 2 V for up to 5 s. With this procedure, we could remove one to six bromine atoms and ultimately generate cyclo[18]carbon from C18Br6 in a yield of ∼64% (for details on the statistics and the process, see the Supporting Information, Sections 6 and 7). Thus, cyclo[18]carbon could be generated more reliably and in higher yield than in previous work, from a cyclocarbon oxide precursor.[18]carbon. Science. 2019 ">3] The increased yield of formation of cyclo[18]carbon is probably a consequence of the lower voltage required for unmasking. AFM images of cyclo[18]carbon synthesized from C18Br6 were recorded at several different tip–sample distances (Figure e–h). Cyclo[18]carbon adsorbs in a nonplanar geometry on bilayer NaCl.[18]carbon. Science. 2019 ">3] The plane for constant-height imaging was adjusted by 4° with respect to the NaCl surface to tilt the imaging plane approximately parallel to the molecular plane, so as to obtain a uniform contrast across the molecule. The dark features next to the cyclo[18]carbon molecule in Figure e (bottom and left), which become bright in Figure h, can be assigned to the dissociated bromine atoms. These dissociated Br atoms were found to stabilize and prevent motion of the cyclo[18]carbon molecules (see also Figures S3 and S4, Supporting Information), which is advantageous for high-resolution AFM imaging: it enabled us to obtain AFM data for C18 with improved resolution and data sets with different tip heights on the same molecule without moving it (Figure e–h).

As reported for cyclo[18]carbon formed from C24O6, the molecule shows nine bright lobes in the AFM images recorded at larger tip–sample distances (Figure e,f) that transition into nine corners for smaller tip–sample distances (Figure g,h). The nine bright lobes are assigned to the triple bonds. The experimental AFM images of C18 (Figure e–h) were compared with simulated images of C18 using the probe particle model[15] based on model geometries A–D with different degrees of BLA and BAA. Bond lengths and bond angles were adopted from previously published high level ab initio CCSD theory calculations with the cc-pVDZ basis set (C18 cumulene: d1 = d2 = 1.30 Å, θ1 = θ2 = 160°; D9 polyyne: d1 = 1.38 Å, d2 = 1.24 Å, θ1 = θ2 = 160°; D9 cumulene: d1 = d2 = 1.30 Å, θ1 = 157.2°, θ2 = 162.9°; C9 polyyne: d1 = 1.38 Å, d2 = 1.24 Å, θ1 = 156.7°, θ2 = 163.3°).[9] The differences in BLA between the cumulenic and polyynic structures produce distinct changes in the simulated images, while differences in BAA lead to less pronounced changes (Figure e–l and Supporting Information, Figures S6–S9). To observe the effect of BAA on the AFM contrast and to test whether larger BAA in the D9 cumulene and C9 polyyne would allow a better distinction from the C18 cumulene and D9 polyyne, respectively, we increased the amount of BAA by up to a factor of 4 compared to the theoretically predicted values (see Supporting Information, Figures S6–S9). Figure e–l shows simulated AFM images at two different tip–sample distances for the optimized D18 cumulene and D9 polyyne geometries, as well as the D9 cumulene and C9 polyyne with four times the calculated BAA of ref (9) (C: θ1 = 171.4°, θ2 = 148.6°; D: θ1 = 173.1°, θ2 = 146.9°). BAA strongly affects the simulated contrast of the D9 cumulene for small tip heights (Figure k), and the contrast of the cumulene with large BAA becomes very similar to those of the polyynes (Figure j,l), showing a characteristic nonagon. The corners of the D9 cumulene are located above atom positions, while the corners of the D9 polyyne are above triple bonds (see Supporting Information). Importantly, the polyyne models can be distinguished from both cumulene models at larger tip height (see Figure e,g); only the polyynes exhibit nine bright lobes (Figure f,h) in agreement with the experiment (Figure e,f). Thus, both cumulenic geometries of cyclo[18]carbon (D18 and D9) can be excluded. However, the polyyne geometries (D9 and C9) show almost no change in contrast variations as we varied the BAA, which implies that for the polyyne geometries it is challenging to resolve or quantify the extent of BAA from AFM images. Two factors may contribute to this effect: (i) In the cumulenic geometries, the introduction of BAA corresponds to a significant change in symmetry from D18 to D9 (i.e., from 18-fold to 9-fold symmetry). However, in the polyyne geometries, the introduction of BAA corresponds to a more subtle change in symmetry from D9 to C9, both of which are 9-fold symmetric. (ii) The AFM contrast of the polyynic geometries is dominated by strong modulations around the carbon ring, due to the large differences in the electron density between triple and single bonds, which are enhanced in AFM by relaxations of the CO tip.[19] On the other hand, BAA affects the position and orientation of the bonds without causing large changes in the electron densities of bonds, resulting in relatively subtle contrast modulations.

In conclusion, C18 is generated by debromination of C18Br6 on bilayer NaCl on Cu(111) at 5 K, with a five times greater yield than from C24O6 precursors. AFM simulations of different geometries of C18 showed that BAA can have a considerable effect on the simulated AFM images for the cumulenic structure but is barely visible for the polyyne. The simulations confirm that the cumulene geometries, even those with extreme BAA, can be excluded, corroborating the polyynic structure of C18 on NaCl. However, it is challenging to rule out or quantify BAA in the polyynic geometry. Interaction with the surface may affect the molecular structure, and the structure of C18 in vacuum might be different from that on NaCl.[5a] Our results indicate that debromination of cyclocarbon precursors is a promising route to explore also other cyclo[n]carbons by on-surface chemistry.