Gennaro Riccio1, Nadia Ruocco1, Mirko Mutalipassi1, Maria Costantini1, Valerio Zupo1, Daniela Coppola1,2, Donatella de Pascale1,3, Chiara Lauritano1. 1. Marine Biotechnology Department, Stazione Zoologica Anton Dohrn, CAP, 80121 Naples, Italy. 2. Institute of Biosciences and BioResources (IBBR), National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy. 3. Institute of Biochemistry and Cell Biology (IBBC), National Research Council, Via Pietro Castellino 111, 80131 Naples, Italy.
Abstract
Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.
Oceans cover more than 70 percent of the surface of our planet and are characterized by huge taxonomic and chemical diversity of marine organisms. Several studies pan class="Species">have shown that marine organisms produce a variety of compounds, derived from primary or secondary metabolism, which may pan class="Species">have antiviral activities. In particular, certain marine metabolites are active towards a plethora of viruses. Multiple mechanisms of action have been found, as well as different targets. This review gives an overview of the marine-derived compounds discovered in the last 10 years. Even if marine organisms produce a wide variety of different compounds, there is only one compound available on the market, Ara-A, and only another one is in phase I clinical trials, named Griffithsin. The recent pandemic emergency caused by SARS-CoV-2, also known as COVID-19, highlights the need to further invest in this field, in order to shed light on marine compound potentiality and discover new drugs from the sea.
Authors: Alberto Falco; Mikolaj Adamek; Patricia Pereiro; David Hoole; José Antonio Encinar; Beatriz Novoa; Ricardo Mallavia Journal: Mar Drugs Date: 2022-05-28 Impact factor: 6.085