Literature DB >> 32643900

Substantial Elevation of Liver Enzymes During Ketamine Infusion: A Case Report.

Xiaoying Zhu1, Lynn R Kohan, Robert B Goldstein.   

Abstract

Intravenous infusion of a subanesthetic dose of ketamine has been shown to improve neuropathic pain. However, ketamine-induced liver injury can occur. Reported here are 2 cases with substantial liver enzyme elevations less than 2 days after initiation of repeat ketamine infusion at least 7 months after the last infusion. Although their liver enzymes normalized within a few weeks, it is unclear what the long-term consequences are. Furthermore, drug-induced liver injury can cause acute liver failure. Therefore, we recommend close monitoring of liver enzymes every 1 to 2 days during ketamine infusions.

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Year:  2020        PMID： 32643900      PMCID： PMC7323839          DOI： 10.1213/XAA.0000000000001239

Source DB:  PubMed          Journal:  A A Pract        ISSN： 2575-3126


  14 in total

1.  Intravenous ketamine for CRPS: Making too much of too little?

Authors:  R F Bell; R A Moore
Journal:  Pain       Date:  2010-03-26       Impact factor: 6.961

Review 2.  Drug-induced liver injury: Diagnosing (and treating) it early.

Authors:  Nandhini Mohankumar; Piyush Ranjan; Archana Kumari
Journal:  J Fam Pract       Date:  2015-10       Impact factor: 0.493

3.  Changes in serum enzyme levels following ketamine infusions.

Authors:  J W Dundee; J P Fee; J Moore; P D McIlroy; D B Wilson
Journal:  Anaesthesia       Date:  1980-01       Impact factor: 6.955

4.  Drug-Induced Liver Injury - Types and Phenotypes.

Authors:  Sahaj Rathi; Pramod Kumar
Journal:  N Engl J Med       Date:  2019-10-03       Impact factor: 91.245

5.  Drug-induced liver injury following a repeated course of ketamine treatment for chronic pain in CRPS type 1 patients: a report of 3 cases.

Authors:  Ingeborg M Noppers; Marieke Niesters; Leon P H J Aarts; Martin C R Bauer; Asbjørn M Drewes; Albert Dahan; Elise Y Sarton
Journal:  Pain       Date:  2011-05-04       Impact factor: 6.961

6.  Multi-day low dose ketamine infusion as adjuvant to oral gabapentin in spinal cord injury related chronic pain: a prospective, randomized, double blind trial.

Authors:  Yasser Mohamed Amr
Journal:  Pain Physician       Date:  2010 May-Jun       Impact factor: 4.965

7.  Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1.

Authors:  Marnix J Sigtermans; Jacobus J van Hilten; Martin C R Bauer; Sesmu M Arbous; Johan Marinus; Elise Y Sarton; Albert Dahan
Journal:  Pain       Date:  2009-07-14       Impact factor: 6.961

8.  Side effects of ketamine in the long-term treatment of neuropathic pain.

Authors:  Petr Cvrcek
Journal:  Pain Med       Date:  2008-03       Impact factor: 3.750

9.  Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.

Authors:  Graeme E Correll; Jahangir Maleki; Edward J Gracely; Jesse J Muir; Ronald E Harbut
Journal:  Pain Med       Date:  2004-09       Impact factor: 3.750

10.  Chronic ketamine administration impairs mitochondrial complex I in the rat liver.

Authors:  Carlos Venâncio; Luís Antunes; Luís Félix; Paula Rodrigues; Teresa Summavielle; Francisco Peixoto
Journal:  Life Sci       Date:  2013-08-11       Impact factor: 5.037
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  1 in total

Review 1.  Prevention and Management of Common Adverse Effects of Ketamine and Esketamine in Patients with Mood Disorders.

Authors:  Felicia Ceban; Joshua D Rosenblat; Kevin Kratiuk; Yena Lee; Nelson B Rodrigues; Hartej Gill; Mehala Subramaniapillai; Flora Nasri; Leanna M W Lui; Orly Lipsitz; Anil Kumar; Jung Goo Lee; Edmond H Chau; Bing Cao; Kangguang Lin; Roger C Ho; Rodrigo B Mansur; Jennifer Swainson; Roger S McIntyre
Journal:  CNS Drugs       Date:  2021-08-07       Impact factor: 5.749
  1 in total

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