| Literature DB >> 3264309 |
M Ogata1, H Lorberboum-Galski, D FitzGerald, I Pastan.
Abstract
IL-2-PE40 is a chimeric molecule in which IL-2 is attached to the amino end of modified Pseudomonas exotoxin molecule lacking cell recognition domain. This molecule was extremely toxic for Con A-stimulated spleen cells from mice. Moreover, IL-2-PE40 has suppressive effect against Ag-activated cells; it inhibits the generation of cytotoxic T lymphocyte activity in a MLC. IL-2-PE40 could be a useful agent in IL-2R targeting therapy including immunosuppressive therapy for allograft rejection or some autoimmune diseases.Entities:
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Year: 1988 PMID： 3264309
Source DB: PubMed Journal: J Immunol ISSN： 0022-1767 Impact factor: 5.422