Hesham Elghazaly1, Nicolas Mottet2, Jorge Garcia3, Stephane Oudard4, Mack Roach5, Claude Abbou6, Axel Merseburger7, Amr Emara8, Samir Shehata9, Hesham Tawfik10, Ola Khorshid11, Ahmed Selim12, Akram Assem13, Khalid Abdelkarim14, Lobna Ezz El-Arab14, Shouki Bazarbashi15, Abbass Omar16, Hesham Elwakil14, Mohamed Elashry17, Mohamed Abou ElFotouh18, Tarek Osman19, Mai Ezz El Din14. 1. Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. heshamelghazaly@hotmail.com. 2. Department of Urology, University Hospital Nord St. Etienne, St. Etienne, France. 3. Department of Solid Tumor Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA. 4. Department of Medical Oncology, Georges Pompidou European Hospital, Paris, France. 5. Department of Radiation Oncology, University of California, San Francisco, CA, USA. 6. Department of Urology, Hôpital Henri Mondor, Creteil, France. 7. Department of Urology and Urologic Oncology, Campus Lübeck, University Hospital Schleswig-Holstein, Lübeck, Germany. 8. Department of Urology, Hampshire Hospitals, NHS Foundation Trust, Basingstoke, UK. 9. Clinical Oncology Department, Assiut University Cancer Centre, Assiut, Egypt. 10. Clinical Oncology Department, Tanta University, Tanta, Egypt. 11. Medical Oncology Department National Cancer Institute, Cairo University, Cairo, Egypt. 12. Clinical Oncology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. 13. Urology Department, Alexandria University, Alexandria, Egypt. 14. Clinical Oncology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. 15. Medical Oncology Department, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia. 16. Department of Clinical Oncology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. 17. Department of Clinical Oncology, Faculty of Medicine, Mansoura University, Mansoura, Egypt. 18. Department of Clinical Oncology, Faculty of Medicine, Menoufia University, Al Minufya, Egypt. 19. Department of Urology, Ain Shams University, Cairo, Egypt.
Abstract
PURPOSE: Advancements in the diagnosis and treatment of prostate cancer (PC) have rapidly progressed through the past years. Various factors should be taken into account while treating individual patients to ensure optimal and careful decision making. The purpose of this consensus review is to summarize the current practice patterns when managing patients with advanced prostate cancer (APC) as there is still a lack of or very limited evidence on its clinical management in some areas. METHODS: Pre-defined questions were shared with experts prior to the consensus session that took place in Cairo, Egypt in April 2019 during the 8th International gastrointestinal, liver and uro-oncology conference (IGILUC). Voting was based mainly on the expert opinions of the panel after a thorough discussion and review of available evidence from guidelines or best evidence available concerning the topic at hand. RESULTS: A strong consensus or unanimity was reached on 47% of the proposed questions. Notably, the panelists reached consensus on several topics based on high-level expert opinion. These findings contribute in several ways to our understanding of the management of PC and provide a basis for future recommendations. There was also a lack of consensus on other several topics, which suggests the need for further supporting data addressing these knowledge gaps. CONCLUSION: This review offers a thorough understanding of APC practice and offers insight on the various opinions shared amongst experts in the field that can serve as guidance regionally and deepens our understanding of disease management globally.
PURPOSE: Advancements in the diagnosis and treatment of prostate cancer (PC) have rapidly progressed through the past years. Various factors should be taken into account while treating individual patients to ensure optimal and careful decision making. The purpose of this consensus review is to summarize the current practice patterns when managing patients with advanced prostate cancer (APC) as there is still a lack of or very limited evidence on its clinical management in some areas. METHODS: Pre-defined questions were shared with experts prior to the consensus session that took place in Cairo, Egypt in April 2019 during the 8th International gastrointestinal, liver and uro-oncology conference (IGILUC). Voting was based mainly on the expert opinions of the panel after a thorough discussion and review of available evidence from guidelines or best evidence available concerning the topic at hand. RESULTS: A strong consensus or unanimity was reached on 47% of the proposed questions. Notably, the panelists reached consensus on several topics based on high-level expert opinion. These findings contribute in several ways to our understanding of the management of PC and provide a basis for future recommendations. There was also a lack of consensus on other several topics, which suggests the need for further supporting data addressing these knowledge gaps. CONCLUSION: This review offers a thorough understanding of APC practice and offers insight on the various opinions shared amongst experts in the field that can serve as guidance regionally and deepens our understanding of disease management globally.
Entities:
Keywords:
Advanced prostate cancer; Consensus; Metastatic prostate cancer; Prostate cancer
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