Literature DB >> 3264208

Immunocytochemical analysis of calcitonin gene-related peptide and vasoactive intestinal polypeptide in Merkel cells and cutaneous free nerve endings of cats.

F J Alvarez1, C Cervantes, R Villalba, I Blasco, R Martínez-Murillo, J M Polak, J Rodrigo.   

Abstract

Calcitonin gene-related peptide (CGRP)- and vasoactive intestinal polypeptide (VIP)-immunoreactivity were observed to coexist in Merkel cells of cats. No differences in peptide content were found between Merkel cells located in epithelia of the hard palate, in hairy and glabrous skin of the upper lip, and in vibrissae follicles. CGRP- and VIP-immunoreactive nerve fibres were also found near CGRP/VIP-immunoreactive Merkel cells. In the vibrissae follicles some CGRP- and VIP-immunoreactive nerve terminals end abutting on the glassy membrane. Other CGRP-immunoreactive nerve fibres penetrate the epithelium of the skin and end within it. Electron microscopy of vibrissae follicles revealed that Merkel cell neurites are not immunostained and that immunostained nerve fibres form unmyelinated bundles before ending freely. Thus, CGRP- and VIP-immunoreactive nerve fibres in cat skin do not end as Merkel cell neurites but as different kinds of free nerve endings.

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Year:  1988        PMID： 3264208     DOI： 10.1007/bf00225816

Source DB:  PubMed          Journal:  Cell Tissue Res        ISSN： 0302-766X            Impact factor:   5.249


  30 in total

1.  FUNCTIONAL SIGNIFICANCE OF THE SUBMICROSCOPICAL, HISTOCHEMICAL AND MICROSCOPICAL ORGANIZATION OF THE CUTANEOUS RECEPTOR ORGANS.

Authors:  N CAUNA
Journal:  Verh Anat Ges       Date:  1963

2.  The free penicillate nerve endings of the human hairy skin.

Authors:  N Cauna
Journal:  J Anat       Date:  1973-07       Impact factor: 2.610

3.  Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: a study on pituitary glands of the rat.

Authors:  P K Nakane
Journal:  J Histochem Cytochem       Date:  1968-09       Impact factor: 2.479

4.  The sensory innervation of primate facial skin. I. Hairy skin.

Authors:  B L Munger; Z Halata
Journal:  Brain Res       Date:  1983-01       Impact factor: 3.252

5.  Fine structure of myelinated mechanical nociceptor endings in cat hairy skin.

Authors:  L Kruger; E R Perl; M J Sedivec
Journal:  J Comp Neurol       Date:  1981-05-01       Impact factor: 3.215

6.  VIP-immunoreactivity in the skin of various mammals: immunohistochemical, radioimmunological and experimental evidence for a dual localization in cutaneous nerves and merkel cells.

Authors:  W Hartschuh; M Reinecke; E Weihe; N Yanaihara
Journal:  Peptides       Date:  1984 Mar-Apr       Impact factor: 3.750

7.  Co-localization of calcitonin gene-related peptide-like immunoreactivity with substance P in cutaneous, vascular and visceral sensory neurons of guinea pigs.

Authors:  I L Gibbins; J B Furness; M Costa; I MacIntyre; C J Hillyard; S Girgis
Journal:  Neurosci Lett       Date:  1985-06-12       Impact factor: 3.046

8.  Neuron-specific enolase in the Merkel cells of mammalian skin. The use of specific antibody as a simple and reliable histologic marker.

Authors:  J Gu; J M Polak; F J Tapia; P J Marangos; A G Pearse
Journal:  Am J Pathol       Date:  1981-07       Impact factor: 4.307

9.  Presence of calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity in intraepidermal free nerve endings of cat skin.

Authors:  F J Alvarez; C Cervantes; I Blasco; R Villalba; R Martinez-Murillo; J M Polak; J Rodrigo
Journal:  Brain Res       Date:  1988-03-01       Impact factor: 3.252

10.  Primary sensory neurons of the rat showing calcitonin gene-related peptide immunoreactivity and their relation to substance P-, somatostatin-, galanin-, vasoactive intestinal polypeptide- and cholecystokinin-immunoreactive ganglion cells.

Authors:  G Ju; T Hökfelt; E Brodin; J Fahrenkrug; J A Fischer; P Frey; R P Elde; J C Brown
Journal:  Cell Tissue Res       Date:  1987-02       Impact factor: 5.249
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  7 in total

1.  Calcitonin gene-related peptide (CGRP) immunoreactivity in the neuroendocrine Merkel cells and nerve fibres of pig and human skin.

Authors:  T García-Caballero; R Gallego; E Rosón; M Fraga; A Beiras
Journal:  Histochemistry       Date:  1989

2.  Ectopic Atoh1 expression drives Merkel cell production in embryonic, postnatal and adult mouse epidermis.

Authors:  Stephen M Ostrowski; Margaret C Wright; Alexa M Bolock; Xuehui Geng; Stephen M Maricich
Journal:  Development       Date:  2015-07-02       Impact factor: 6.868

Review 3.  Merkel cells and neurons keep in touch.

Authors:  Seung-Hyun Woo; Ellen A Lumpkin; Ardem Patapoutian
Journal:  Trends Cell Biol       Date:  2014-12-02       Impact factor: 20.808

Review 4.  Distribution patterns of the paraneuronal endocrine cells in the skin, gills and the airways of fishes as determined by immunohistochemical and histological methods.

Authors:  G Zaccone; S Fasulo; L Ainis
Journal:  Histochem J       Date:  1994-08

5.  Postnatal development of autonomic and sensory innervation of thoracic hairy skin in the rat. A histochemical, immunocytochemical, and radioenzymatic study.

Authors:  R J Schotzinger; S C Landis
Journal:  Cell Tissue Res       Date:  1990-05       Impact factor: 5.249

6.  Neural cell adhesion molecule immunoreactivity in Merkel cells and Merkel cell tumours.

Authors:  R Gallego; T García-Caballero; M Fraga; A Beiras; J Forteza
Journal:  Virchows Arch       Date:  1995       Impact factor: 4.064

7.  Merkel cells, a new localization of prepro-orexin and orexin receptors.

Authors:  Andrés Beiras-Fernández; Rosalía Gallego; Montserrat Blanco; Tomás García-Caballero; Carlos Diéguez; Andrés Beiras
Journal:  J Anat       Date:  2004-02       Impact factor: 2.610
  7 in total

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