Literature DB >> 3264180

Ultrastructural studies of a lysosomal enzyme during lymphocyte activation.

G Bou-Gharios1, J Moss, D Abraham, T Partridge, I Olsen.   

Abstract

A post-embedding immunogold technique has been used for the ultrastructural localization of a lysosomal enzyme, beta-glucuronidase, in resting and activated T- and B-lymphocytes. The results presented here show that mitogen-induced stimulation of T- and B-cells was associated with an increase in the amount of enzyme in the Golgi complex and rough endoplasmic reticulum, organelles which were rarely present in the resting lymphocytes.

Entities:  

Mesh:

Substances:

Year:  1988        PMID: 3264180      PMCID: PMC2013276     

Source DB:  PubMed          Journal:  Br J Exp Pathol        ISSN: 0007-1021


  28 in total

1.  Lysosomal acid hydrolases in human lymphocyte subpopulations.

Authors:  R D Barr; S Perry
Journal:  Br J Haematol       Date:  1976-04       Impact factor: 6.998

2.  LYSOSOMES IN DIVIDING CELLS, WITH SPECIAL REFERENCE TO LYMPHOCYTES.

Authors:  A C ALLISON; L MALLUCCI
Journal:  Lancet       Date:  1964-12-26       Impact factor: 79.321

3.  Acid hydrolases in normal B and T blood lymphocytes.

Authors:  G A Pangalis; W Kuhl; S R Waldman; E Beutler
Journal:  Acta Haematol       Date:  1978       Impact factor: 2.195

4.  The lymphocyte beta-glucuronidase activity in lymphoproliferative disorders.

Authors:  L T Yam; W J Mitus
Journal:  Blood       Date:  1968-04       Impact factor: 22.113

5.  Lymphocyte lysosomes and lysosomal enzymes in chronic lymphocytic leukemia.

Authors:  S D Douglas; G Cohnen; E König; G Brittinger
Journal:  Blood       Date:  1973-04       Impact factor: 22.113

6.  Lymphocyte activation. II. discriminating stimulation of lymphocyte subpopulations by phytomitogens and heterologous antilymphocyte sera.

Authors:  G Janossy; M F Greaves
Journal:  Clin Exp Immunol       Date:  1972-03       Impact factor: 4.330

7.  The morphologic and cytochemical demonstration of lysosomes in lymphocytes incubated with phytohemagglutinin by electron microscopy.

Authors:  J W Parker; H Wakasa; R J Lukes
Journal:  Lab Invest       Date:  1965-10       Impact factor: 5.662

8.  Lymphocyte activation. I. Response of T and B lymphocytes to phytomitogens.

Authors:  G Janossy; M F Greaves
Journal:  Clin Exp Immunol       Date:  1971-10       Impact factor: 4.330

9.  Acid hydrolases in leukocytes and platelets of normal subjects and in patients with Gaucher's and Fabry's disease.

Authors:  E Beutler; W Kuhl; F Matsumoto; G Pangalis
Journal:  J Exp Med       Date:  1976-04-01       Impact factor: 14.307

10.  Studies on lysosomes. XII. Redistribution of acid hydrolases in human lymphocytes stimulated by phytohemagglutinin.

Authors:  R Hirschhorn; G Brittinger; K Hirschhorn; G Weissmann
Journal:  J Cell Biol       Date:  1968-05       Impact factor: 10.539

View more
  2 in total

Review 1.  Lysosomal storage diseases: mechanisms of enzyme replacement therapy.

Authors:  G Bou-Gharios; D Abraham; I Olsen
Journal:  Histochem J       Date:  1993-09

2.  Localization of lysosomal antigens in activated T-lymphocytes.

Authors:  G Bou-Gharios; J Moss; I Olsen
Journal:  Histochem J       Date:  1991-10
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.