Literature DB >> 3264172

A unique human immunodeficiency virus culture secreting soluble gp160.

V S Kalyanaraman1, R Pal, R C Gallo, M G Sarngadharan.   

Abstract

A clone of the HUT78 cell line, chronically infected with the HIV-1 isolate HTLV-III451, has been demonstrated to secrete unprocessed HIV-1 envelope precursor protein gp160 as well as mature gp120. Further, when grown in serum-free defined medium these cells released approximately five times the amount of virus compared with cultures in normal medium. These proteins corresponded in their immunologic reactivities with the respective envelope proteins of the HTLV-IIIB isolate. They formed high-affinity soluble complexes with the CD4 antigen and inhibited the syncytium formation induced by HTLV-IIIB on CD4-positive cells. This is the first description of an HIV-1 culture system capable of shedding into the medium native gp160 that is soluble in the absence of detergents.

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Year:  1988        PMID： 3264172     DOI： 10.1089/aid.1988.4.319

Source DB:  PubMed          Journal:  AIDS Res Hum Retroviruses        ISSN： 0889-2229            Impact factor:   2.205


  16 in total

1.  Cystein 402 of HIV gp 120 is essential for CD4-binding and resistance of gp 120 to intracellular degradation.

Authors:  A Hemming; A Bolmstedt; P Flodby; L Lundberg; M Gidlund; H Wigzell; S Olofsson
Journal:  Arch Virol       Date:  1989       Impact factor: 2.574

2.  Crosslinked HIV-1 envelope-CD4 receptor complexes elicit broadly cross-reactive neutralizing antibodies in rhesus macaques.

Authors:  Timothy Fouts; Karla Godfrey; Kathryn Bobb; David Montefiori; Carl V Hanson; V S Kalyanaraman; Anthony DeVico; Ranajit Pal
Journal:  Proc Natl Acad Sci U S A       Date:  2002-08-21       Impact factor: 11.205

3.  Increased HIV-1 production in chronically infected H9 cells grown in protein-free medium.

Authors:  J Cinatl; J Cinatl; H Rabenau; U Ebener; B Kornhuber; H W Doerr
Journal:  Arch Virol       Date:  1992       Impact factor: 2.574

4.  Requirement of the T cell receptor for antigen presentation by T lymphocytes. Effect of envelope glycoproteins of HIV-1 on antigen presentation by T cells.

Authors:  N Chirmule; V S Kalyanaraman; H Slade; N Oyaizu; S Pahwa
Journal:  Clin Exp Immunol       Date:  1990-05       Impact factor: 4.330

5.  Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA.

Authors:  N Oyaizu; N Chirmule; V S Kalyanaraman; W W Hall; R Pahwa; M Shuster; S Pahwa
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

6.  Systemic immunization with an ALVAC-HIV-1/protein boost vaccine strategy protects rhesus macaques from CD4+ T-cell loss and reduces both systemic and mucosal simian-human immunodeficiency virus SHIVKU2 RNA levels.

Authors:  Ranajit Pal; David Venzon; Sampa Santra; Vaniambadi S Kalyanaraman; David C Montefiori; Lindsey Hocker; Lauren Hudacik; Nicolas Rose; Janos Nacsa; Yvette Edghill-Smith; Marcin Moniuszko; Zdenek Hel; Igor M Belyakov; Jay A Berzofsky; Robyn Washington Parks; Phillip D Markham; Norman L Letvin; Jim Tartaglia; Genoveffa Franchini
Journal:  J Virol       Date:  2006-04       Impact factor: 5.103

Review 7.  Role of p53 in neurodegenerative diseases.

Authors:  J Robert Chang; Mohammad Ghafouri; Ruma Mukerjee; Asen Bagashev; Tinatin Chabrashvili; Bassel E Sawaya
Journal:  Neurodegener Dis       Date:  2011-10-28       Impact factor: 2.977

8.  Antibodies with specificity to native gp120 and neutralization activity against primary human immunodeficiency virus type 1 isolates elicited by immunization with oligomeric gp160.

Authors:  T C VanCott; J R Mascola; R W Kaminski; V Kalyanaraman; P L Hallberg; P R Burnett; J T Ulrich; D J Rechtman; D L Birx
Journal:  J Virol       Date:  1997-06       Impact factor: 5.103

9.  Conditional infectivity of a human immunodeficiency virus matrix domain deletion mutant.

Authors:  C T Wang; Y Zhang; J McDermott; E Barklis
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

10.  Mutation in the primer binding site of the type 1 human immunodeficiency virus genome affects virus production and infectivity.

Authors:  T Nagashunmugam; A Velpandi; C S Goldsmith; S R Zaki; V S Kalyanaraman; A Srinivasan
Journal:  Proc Natl Acad Sci U S A       Date:  1992-05-01       Impact factor: 11.205
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