| Literature DB >> 32641488 |
Yuumi Nakamura1,2, Hiroki Takahashi3,4, Akiko Takaya5, Yuzaburo Inoue6, Yuki Katayama7, Yoko Kusuya3, Tatsuma Shoji5, Sanami Takada7, Seitaro Nakagawa7, Rena Oguma7, Nobuko Saito7, Naoko Ozawa6, Taiji Nakano6, Fumiya Yamaide6, Eishika Dissanayake6, Shuichi Suzuki8, Amer Villaruz9, Saranyaraajan Varadarajan10, Masanori Matsumoto10, Tomoko Kobayashi11, Michihiro Kono11, Yasunori Sato12, Masashi Akiyama11, Michael Otto9, Hiroyuki Matsue7,3, Gabriel Núñez10, Naoki Shimojo6.
Abstract
Atopic dermatitis (AD) is commonly associated with colonization by Staphylococcus aureus in the affected skin. To understand the role of S. aureus in the development of AD, we performed whole-genome sequencing of S. aureus strains isolated from the cheek skin of 268 Japanese infants 1 and 6 months after birth. About 45% of infants were colonized with S. aureus at 1 month regardless of AD outcome. In contrast, skin colonization by S. aureus at 6 months of age increased the risk of developing AD. Acquisition of dysfunctional mutations in the S. aureus Agr quorum-sensing (QS) system was primarily observed in strains from 6-month-old infants who did not develop AD. Expression of a functional Agr system in S. aureus was required for epidermal colonization and the induction of AD-like inflammation in mice. Thus, retention of functional S. aureus agr virulence during infancy is associated with pathogen skin colonization and the development of AD.Entities:
Mesh：
Year: 2020 PMID： 32641488 PMCID： PMC7426015 DOI： 10.1126/scitranslmed.aay4068
Source DB: PubMed Journal: Sci Transl Med ISSN： 1946-6234 Impact factor: 17.956