| Literature DB >> 3264135 |
R Denays1, M Rubinstein, H Ham, A Piepsz, P Noël.
Abstract
Fourteen children with various seizure disorders were studied using a cerebral blood flow tracer, 123I iodoamphetamine (0.05 mCi/kg), and single photon emission computed tomography (SPECT). In the five patients with radiological lesions, SPECT showed congruent or more extensive abnormalities. Five of the nine children with a normal scan on computed tomography had abnormal SPECT studies consisting of focal hypoperfusion, diffuse hemispheric hypoperfusion, multifocal and bilateral hypoperfusion, or focal hyperperfusion. A focal lesion seen on SPECT has been found in children with tonic-clonic seizures suggesting secondarily generalised seizures. Moreover the pattern seen on SPECT seemed to be related to the clinical status. An extensive impairment found on SPECT was associated with a poor evolution in terms of intellectual performance and seizure frequency. Conversely all children with a normal result on SPECT had less than two seizures per year and normal neurological and intellectual development.Entities:
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Year: 1988 PMID： 3264135 PMCID： PMC1779044 DOI： 10.1136/adc.63.10.1184
Source DB: PubMed Journal: Arch Dis Child ISSN： 0003-9888 Impact factor: 3.791