The Biology and Therapeutic Potential of Mesenchymal Stem Cells derived Exosomes.

Mesenchymal stem cells (MSCs) are multipotent stromal cells with the potential to differentiate into several cell types. MSCs-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSCs are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in the intercellular communication via transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition, biological functions, as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities. This article is protected by copyright. All rights reserved.