Literature DB >> 32639040

CCR5 deficiency/CCR5Δ32: resistant to HIV infection at the cost of curtailed CD4+ T cell memory responses.

Christoph Matti1, Daniel F Legler1,2,3.   

Abstract

Orchestrated trafficking and activation by pathogen-derived peptides define the ability of CD4+ T helper cells to contribute to an effective adaptive immunity. In this issue of The EMBO Journal, Martín-Leal et al show that the inflammatory chemokine receptor CCR5, well known for its role in cell migration and HIV infection, regulates ceramide synthesis and TCR nanoclustering to promote memory CD4+ T cell activation.
© 2020 The Authors.

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Year:  2020        PMID： 32639040      PMCID： PMC7396855          DOI： 10.15252/embj.2020105854

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  11 in total

1.  Cross-talk between TCR and CCR7 signaling sets a temporal threshold for enhanced T lymphocyte migration.

Authors:  Karin Schaeuble; Mark A Hauser; Eva Singer; Marcus Groettrup; Daniel F Legler
Journal:  J Immunol       Date:  2011-10-31       Impact factor: 5.422

2.  T cell costimulation by chemokine receptors.

Authors:  Barbara Molon; Giorgia Gri; Monica Bettella; Concepción Gómez-Moutón; Antonio Lanzavecchia; Carlos Martínez-A; Santos Mañes; Antonella Viola
Journal:  Nat Immunol       Date:  2005-04-10       Impact factor: 25.606

3.  A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells.

Authors:  Jun Huang; Mario Brameshuber; Xun Zeng; Jianming Xie; Qi-jing Li; Yueh-hsiu Chien; Salvatore Valitutti; Mark M Davis
Journal:  Immunity       Date:  2013-10-10       Impact factor: 31.745

4.  Increased sensitivity of antigen-experienced T cells through the enrichment of oligomeric T cell receptor complexes.

Authors:  Rashmi Kumar; María Ferez; Mahima Swamy; Ignacio Arechaga; María Teresa Rejas; Jose M Valpuesta; Wolfgang W A Schamel; Balbino Alarcon; Hisse M van Santen
Journal:  Immunity       Date:  2011-09-08       Impact factor: 31.745

5.  Chemokines enhance immunity by guiding naive CD8+ T cells to sites of CD4+ T cell-dendritic cell interaction.

Authors:  Flora Castellino; Alex Y Huang; Grégoire Altan-Bonnet; Sabine Stoll; Clemens Scheinecker; Ronald N Germain
Journal:  Nature       Date:  2006-04-13       Impact factor: 49.962

6.  The chemokine receptor CCR5 plays a key role in the early memory CD8+ T cell response to respiratory virus infections.

Authors:  Jacob E Kohlmeier; Shannon C Miller; Joanna Smith; Bao Lu; Craig Gerard; Tres Cookenham; Alan D Roberts; David L Woodland
Journal:  Immunity       Date:  2008-07-18       Impact factor: 31.745

Review 7.  Modulation of Chemokine Receptor Function by Cholesterol: New Prospects for Pharmacological Intervention.

Authors:  Daniel F Legler; Christoph Matti; Julia M Laufer; Barbara D Jakobs; Vladimir Purvanov; Edith Uetz-von Allmen; Marcus Thelen
Journal:  Mol Pharmacol       Date:  2017-01-12       Impact factor: 4.436

8.  Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration.

Authors:  Mark A Hauser; Karin Schaeuble; Ilona Kindinger; Daniela Impellizzieri; Wolfgang A Krueger; Christof R Hauck; Onur Boyman; Daniel F Legler
Journal:  Immunity       Date:  2016-01-19       Impact factor: 31.745

9.  CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis.

Authors:  Ana Martín-Leal; Raquel Blanco; Josefina Casas; María E Sáez; Elena Rodríguez-Bovolenta; Itziar de Rojas; Carina Drechsler; Luis Miguel Real; Gemma Fabrias; Agustín Ruíz; Mario Castro; Wolfgang Wa Schamel; Balbino Alarcón; Hisse M van Santen; Santos Mañes
Journal:  EMBO J       Date:  2020-06-11       Impact factor: 11.598

Review 10.  International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors.

Authors:  Francoise Bachelerie; Adit Ben-Baruch; Amanda M Burkhardt; Christophe Combadiere; Joshua M Farber; Gerard J Graham; Richard Horuk; Alexander Hovard Sparre-Ulrich; Massimo Locati; Andrew D Luster; Alberto Mantovani; Kouji Matsushima; Philip M Murphy; Robert Nibbs; Hisayuki Nomiyama; Christine A Power; Amanda E I Proudfoot; Mette M Rosenkilde; Antal Rot; Silvano Sozzani; Marcus Thelen; Osamu Yoshie; Albert Zlotnik
Journal:  Pharmacol Rev       Date:  2013-11-11       Impact factor: 25.468
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  3 in total

Review 1.  The Role of Innate Immunity in Natural Elite Controllers of HIV-1 Infection.

Authors:  Yuting Shi; Jinming Su; Rongfeng Chen; Wudi Wei; Zongxiang Yuan; Xiu Chen; Xinwei Wang; Hao Liang; Li Ye; Junjun Jiang
Journal:  Front Immunol       Date:  2022-02-08       Impact factor: 7.561

Review 2.  CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population.

Authors:  Bruna Kulmann-Leal; Joel Henrique Ellwanger; José Artur Bogo Chies
Journal:  Front Immunol       Date:  2021-12-10       Impact factor: 7.561

3.  The Chemokine Receptor CCR5 Links Memory CD4+ T Cell Metabolism to T Cell Antigen Receptor Nanoclustering.

Authors:  Raquel Blanco; Marta Gómez de Cedrón; Laura Gámez-Reche; Ana Martín-Leal; Alicia González-Martín; Rosa A Lacalle; Ana Ramírez de Molina; Santos Mañes
Journal:  Front Immunol       Date:  2021-12-07       Impact factor: 7.561
  3 in total

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