Literature DB >> 32638809

Genetic dereplication driven discovery of a tricinoloniol acid biosynthetic pathway in Trichoderma hypoxylon.

Huan Liu1, Yu-Han Pu2, Jin-Wei Ren3, Er-Wei Li3, Li-Xia Guo2, Wen-Bing Yin1.   

Abstract

A genetic dereplication approach in combination with differential gene expression led to the discovery of three new sesquiterpenes, tricinoloniol acids (TRAs) A-C (1-3) and the known fusidilactone A (4) from T. hypoxylon. Comparative transcriptomic analysis and targeted deletion identified the biosynthetic route for TRAs. Our results demonstrate an alternative application of the genetic dereplication method for exploring the biosynthesis of cryptic secondary metabolites (SMs), which utilizes the coordinated expression of trichothecene (tri) and tra cluster genes.

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Year:  2020        PMID： 32638809     DOI： 10.1039/d0ob01202e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  Sesquiterpenes from the soil-derived fungus Trichoderma citrinoviride PSU-SPSF346.

Authors:  Wiriya Yaosanit; Vatcharin Rukachaisirikul; Souwalak Phongpaichit; Sita Preedanon; Jariya Sakayaroj
Journal:  Beilstein J Org Chem       Date:  2022-04-29       Impact factor: 2.544

Review 2.  Molecular methods unravel the biosynthetic potential of Trichoderma species.

Authors:  Mary L Shenouda; Russell J Cox
Journal:  RSC Adv       Date:  2021-01-18       Impact factor: 3.361

3.  Characterisation of two unique sesquiterpenoids from Trichoderma hypoxylon.

Authors:  Jinyu Zhang; Wen-Bing Yin
Journal:  Mycology       Date:  2021-08-12

4.  Combination Strategy of Genetic Dereplication and Manipulation of Epigenetic Regulators Reveals a Novel Compound from Plant Endophytic Fungus.

Authors:  Lu Yang; Guangwei Wu; Fanyue Meng; Huomiao Ran; Wenbing Yin; Wei Li; Xiaoqing Liu
Journal:  Int J Mol Sci       Date:  2022-03-28       Impact factor: 5.923
  4 in total

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