Literature DB >> 32638757

A supramolecular nanoprodrug based on a boronate ester linked curcumin complexing with water-soluble pillar[5]arene for synergistic chemotherapies.

Shuang Chao1, Xiukai Lv1, Ning Ma1, Ziyan Shen1, Feiyu Zhang1, Yuxin Pei1, Zhichao Pei1.   

Abstract

A supramolecular nanoprodrug based on the host-guest complexation of water-soluble pillar[5]arene (WP5) and a boronate ester linked curcumin (Cur) was constructed, which had dual-responsiveness towards pH and GSH, allowing the drug to be selectively released in hepatoma cells. In vitro studies revealed that the Dox-loaded WP5G-Cur nanoprodrug achieved co-delivery of Dox/Cur. The anti-cancer efficiency could be enhanced through synergistic chemotherapies of Dox/Cur.

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Year:  2020        PMID： 32638757     DOI： 10.1039/d0cc04315j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  Glyconanoparticles with Activatable Near-Infrared Probes for Tumor-Cell Imaging and Targeted Drug Delivery.

Authors:  Guanyu Chi; Yinghua Lv; Shuang Chao; Chenxi Hou; Yuxin Pei; Zhichao Pei
Journal:  Int J Nanomedicine       Date:  2022-04-02

2.  A GSH-Responsive Nanoprodrug System Based on Self-Assembly of Lactose Modified Camptothecin for Targeted Drug Delivery and Combination Chemotherapy.

Authors:  Chenxi Hou; Ning Ma; Ziyan Shen; Guanyu Chi; Shuang Chao; Yuxin Pei; Lan Chen; Yuchao Lu; Zhichao Pei
Journal:  Int J Nanomedicine       Date:  2020-12-22

3.  Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan.

Authors:  Fenghui Qiao; Zhiqi Jiang; Wen Fang; Jingzhi Sun; Qiaoling Hu
Journal:  Int J Mol Sci       Date:  2022-07-01       Impact factor: 6.208

Review 4.  Nanoparticulation of Prodrug into Medicines for Cancer Therapy.

Authors:  Yuezhou Zhang; Huaguang Cui; Ruiqi Zhang; Hongbo Zhang; Wei Huang
Journal:  Adv Sci (Weinh)       Date:  2021-07-29       Impact factor: 16.806

5.  Self-Assembling Systems Based on Pillar[5]arenes and Surfactants for Encapsulation of Diagnostic Dye DAPI.

Authors:  Anastasia Nazarova; Arthur Khannanov; Artur Boldyrev; Luidmila Yakimova; Ivan Stoikov
Journal:  Int J Mol Sci       Date:  2021-06-03       Impact factor: 5.923
  5 in total

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