Fully multi-target segmentation for breast ultrasound image based on fully convolutional network.

Ultrasound image segmentation plays an important role in computer-aided diagnosis of breast cancer. Existing approaches focused on extracting the tumor tissue to characterize the tumor class. However, other tissues are also helpful for providing the references. In this paper, a multi-target semantic segmentation approach is proposed based on the fully convolutional network for segmenting the breast ultrasound image into different target tissue regions. For handling the uncertain affiliation of pixels in blurry boundaries, the certain outputs of pixel characteristics in AlexNet are transformed into the fuzzy decision expression. For improving the image detail representation, the AlexNet network structure of fully convolutional network is optimized with fully connected skip structure. In addition, the output of net model is optimized with fully connected conditional random field to improve the characterization of spatial consistency and pixels' correlation of the image. Moreover, a data training optimization method is developed for improving the efficiency of network training. In the experiment, 325 ultrasound images and four error metrics are utilized for validating the segmentation performance. Comparing with existing methods, experimental results show that the proposed approach is effective for handling the breast ultrasound images accurately and reliably. Graphical abstract.