Koichi Okuya1, Ichiro Takemasa2, Tetsuhiro Tsuruma3, Ai Noda4, Kenichi Sasaki5, Tomomi Ueki3,4, Mitsuhiro Mukaiya4, Keita Saito5, Kenji Okita1, Toshihiko Nishidate1, Emi Akizuki1, Atsushi Hamabe1, Masayuki Ishii1. 1. Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, S1, W16, Chuo-ku, Sapporo, 060-8543, Japan. 2. Department of Surgery, Surgical Oncology and Science, Sapporo Medical University, S1, W16, Chuo-ku, Sapporo, 060-8543, Japan. itakemasa@sapmed.ac.jp. 3. Department of Surgery, JR Sapporo Hospital, N3, E1, Chuo-ku, Sapporo, 060-0033, Japan. 4. Department of Surgery, Otaru Ekisaikai Hospital, 1-4-1 Inaho, Otaru, 047-0032, Japan. 5. Department of Surgery, Muroran City General Hospital, 3-8-1, Yamate-cho, Muroran, 051-8512, Japan.
Abstract
PURPOSE: Surgical site infection (SSI) occurs at a high rate after ileostomy closure. The effect of preventive negative-pressure wound therapy (NPWT) on SSI development in closed wounds remains controversial. We conducted a prospective multicenter study to evaluate the usefulness of preventive NPWT for SSI after ileostomy closure. METHODS: From January 2018 to November 2018, 50 patients who underwent closure of ileostomy created after surgery for colorectal cancer participated in this study. An NPWT device was applied to each wound immediately after surgery and then treatment was continued for 3 days. The primary endpoint was 30-day SSI, and the secondary endpoints were the incidence of seroma, hematoma, and adverse events related to NPWT. RESULTS: No patients developed SSI, seroma, or hematoma. Adverse events that may have been causally linked with NPWT were contact dermatitis in two patients and wound pain in one patient, and there were no cases of discontinuation or decompression of NPWT. CONCLUSION: The use of NPWT following ileostomy closure may be useful for reducing the development of SSI in colorectal cancer patients. This is a prospective multicenter pilot study and we are planning a comparative study based on these successful results. TRAIL REGISTRATION: Registration number: UMIN000032053 ( https://www.umin.ac.jp/ ).
PURPOSE: Surgical site infection (SSI) occurs at a high rate after ileostomy closure. The effect of preventive negative-pressure wound therapy (NPWT) on SSI development in closed wounds remains controversial. We conducted a prospective multicenter study to evaluate the usefulness of preventive NPWT for SSI after ileostomy closure. METHODS: From January 2018 to November 2018, 50 patients who underwent closure of ileostomy created after surgery for colorectal cancer participated in this study. An NPWT device was applied to each wound immediately after surgery and then treatment was continued for 3 days. The primary endpoint was 30-day SSI, and the secondary endpoints were the incidence of seroma, hematoma, and adverse events related to NPWT. RESULTS: No patients developed SSI, seroma, or hematoma. Adverse events that may have been causally linked with NPWT were contact dermatitis in two patients and wound pain in one patient, and there were no cases of discontinuation or decompression of NPWT. CONCLUSION: The use of NPWT following ileostomy closure may be useful for reducing the development of SSI in colorectal cancer patients. This is a prospective multicenter pilot study and we are planning a comparative study based on these successful results. TRAIL REGISTRATION: Registration number: UMIN000032053 ( https://www.umin.ac.jp/ ).
Entities:
Keywords:
Ileostomy closure; Negative-pressure wound therapy; Surgical site infection
Authors: Maciej Borejsza-Wysocki; Adam Bobkiewicz; Wojciech Francuzik; Lukasz Krokowicz; Dominik Walczak; Jacek Szmeja; Tomasz Banasiewicz Journal: Wideochir Inne Tech Maloinwazyjne Date: 2021-05-25 Impact factor: 1.195