Sumedha Prashanth Payyal1, Narayana Charyulu Rompicherla1, Sandeep Divate Sathyanarayana1, Ravi Gundadka Shriram1, Anoop Narayanan Vadakkepushpakath1.
Abstract
OBJECTIVES: Sulconazole is a broad spectrum antifungal agent of the imidazole class used against dermatophytes and other fungi to treat skin infections. The aim of the present work was to formulate and evaluate a microemulsion-based topical sulconazole gel.
MATERIALS AND METHODS: Microemulsion formulation of sulconazole nitrate was prepared by using oil, surfactant, cosurfactant and water at different ratios. This was then subjected to clarity and particle size analysis, a centrifugation test, a dilution test, and freeze thawing.
RESULTS: The zeta potential of formulation F1 was -41.3 and stable. The pH of the microemulsion formulation was within the range of pH of skin. F1 showed a higher percentage amount of drug as compared with the other formulations. The viscosity showed that F1 was optimum. The freezing and thawing results showed there was no phase separation and the formulation was stable. In vitro drug release showed that the drug release from the microemulsion of F1 was higher when compared to the other formulations. It revealed F1 had the highest drug content of 95.88±0.3% and % cumulative drug release was 88.75% release in 8 h. The in vivo skin irritation study on rats confirmed that formulation was nontoxic and nonirritant.
CONCLUSION: The present study confirmed the safety of the formulated sulconazole loaded microemulsion gel for topical application. ©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.
OBJECTIVES: Sulconazole is a broad spectrum antifungal agent of the imidazole class used against dermatophytes and other fungi to treat skin infections. The aim of the present work was to formulate and evaluate a microemulsion-based topical sulconazole gel.
MATERIALS AND METHODS: Microemulsion formulation of sulconazole nitrate was prepared by using oil, surfactant, cosurfactant and water at different ratios. This was then subjected to clarity and particle size analysis, a centrifugation test, a dilution test, and freeze thawing.
RESULTS: The zeta potential of formulation F1 was -41.3 and stable. The pH of the microemulsion formulation was within the range of pH of skin. F1 showed a higher percentage amount of drug as compared with the other formulations. The viscosity showed that F1 was optimum. The freezing and thawing results showed there was no phase separation and the formulation was stable. In vitro drug release showed that the drug release from the microemulsion of F1 was higher when compared to the other formulations. It revealed F1 had the highest drug content of 95.88±0.3% and % cumulative drug release was 88.75% release in 8 h. The in vivo skin irritation study on rats confirmed that formulation was nontoxic and nonirritant.
CONCLUSION: The present study confirmed the safety of the formulated sulconazole loaded microemulsion gel for topical application. ©Copyright 2020 Turk J Pharm Sci, Published by Galenos Publishing House.
Entities:
Keywords:
Microemulsion; fungal infection; in vitro release; sulconazole nitrate
Year: 2020
PMID： 32636702 PMCID： PMC7336032 DOI： 10.4274/tjps.galenos.2019.75537
Source DB: PubMed Journal: Turk J Pharm Sci ISSN： 1304-530X