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Literature DB >> 3263646

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

M Iwashima¹, A Green, M M Davis, Y H Chien.

Abstract

A variable region (V delta 5) of the T-cell receptor (TcR) delta chain that is preferentially expressed in adult murine thymocytes is located 2.5 kilobases 3' of the constant region (C delta) element. The V delta 5 coding sequence is in a transcriptional orientation opposite the J delta (joining region) and C delta coding elements and rearranges by inversion. The C delta is divided into four exons, three of which encode amino acids of TcR delta polypeptide, and the fourth comprises the entire 3' untranslated region. In this respect, C delta resembles C alpha rather than C beta or C gamma.

Entities: Gene Species

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Year: 1988 PMID： 3263646 PMCID： PMC282387 DOI： 10.1073/pnas.85.21.8161

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

Variable region (V delta) gene segment most frequently utilized in adult thymocytes is 3' of the constant (C delta) region.

1. A T-cell receptor gamma/CD3 complex found on cloned functional lymphocytes.

Review 2. T-cell antigen receptor genes and T-cell recognition.

3. Direct evidence for chromosomal inversion during T-cell receptor beta-gene rearrangements.

Review 4. Splicing of messenger RNA precursors.

5. Identification of a putative second T-cell receptor.

6. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes.

Review 7. The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition.

8. Supercoil sequencing: a fast and simple method for sequencing plasmid DNA.

9. Expression of genes of the T-cell antigen receptor complex in precursor thymocytes.

10. Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells.

1. Secretion of a soluble, chimeric gamma delta T-cell receptor-immunoglobulin heterodimer.

2. Alternative splicing of rearranged T cell receptor delta sequences to the constant region of the alpha locus.

3. Concomitant T-cell receptor alpha and delta gene rearrangements in individual T-cell precursors.

4. Analysis of early fetal T-cell receptor delta chain in humans.

Review 5. Helix-Loop-Helix Proteins in Adaptive Immune Development.

Review 6. Mouse T-cell receptor variable gene segment families.

7. Human T-cell-receptor delta chain: genomic organization, diversity, and expression in populations of cells.

8. Genomic organization of the mouse T cell receptor V alpha family.

9. Positive and negative regulation of V(D)J recombination by the E2A proteins.

10. Divergent Evolution of TRC Genes in Mammalian Niche Adaptation.