| Literature DB >> 3263613 |
A G De Volder1, J Jaeken, G Van den Berghe, A Bol, C Michel, M Cogneau, A M Goffinet.
Abstract
Regional brain glucose utilization was investigated by positron emission tomography with fluorodeoxyglucose in three children with adenylosuccinase deficiency. A consistent pattern was found in the three patients, namely a marked decrease of fluorodeoxyglucose uptake in all gray structures, with the exception of the cerebellum, which was minimally affected. Anomalies predominated in the cerebral cortex, particularly in the anterior regions; they were less pronounced in thalamus and basal ganglia. The observations suggest that positron emission tomography may be a useful tool for the localization of the deleterious effects of metabolic diseases and for the investigation of their pathophysiologic mechanisms.Entities:
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Year: 1988 PMID： 3263613 DOI： 10.1203/00006450-198808000-00020
Source DB: PubMed Journal: Pediatr Res ISSN： 0031-3998 Impact factor: 3.756