Literature DB >> 3263593

Release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) from organs of the genitourinary tract in rats.

P Santicioli1, C A Maggi, P Geppetti, E Del Bianco, E Theodorsson, A Meli.   

Abstract

Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was detected in the rat urinary bladder, ureter and vas deferens and was depleted by systemic capsaicin desensitization. Exposure to capsaicin in vitro produced a prompt increase in CGRP-LI outflow in superfusates of these tissues, while a second application of the drug was ineffective indicating desensitization. These findings provide further evidence for a transmitter role of CGRP from peripheral endings of sensory nerves and the involvement of CGRP-LI in the specific motor response to capsaicin in the rat genitourinary tract.

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Year:  1988        PMID： 3263593     DOI： 10.1016/0304-3940(88)90060-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  8 in total

1.  Propagation of impulses in the guinea-pig ureter and its blockade by calcitonin gene-related peptide (CGRP).

Authors:  S Meini; P Santicioli; C A Maggi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-01       Impact factor: 3.000

2.  A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens.

Authors:  C A Maggi; S Bevan; C S Walpole; H P Rang; S Giuliani
Journal:  Br J Pharmacol       Date:  1993-03       Impact factor: 8.739

3.  Multiple mechanisms in the smooth muscle relaxant action of calcitonin gene-related peptide (CGRP) in the guinea-pig ureter.

Authors:  C A Maggi; S Giuliani; P Santicioli
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-11       Impact factor: 3.000

4.  Evidence for the involvement of bradykinin in chemically-evoked cystitis in anaesthetized rats.

Authors:  C A Maggi; P Santicioli; E Del Bianco; A Lecci; S Guliani
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-04       Impact factor: 3.000

5.  Calcitonin gene-related peptide (CGRP)-immunoreactive nerve plexuses in the renal pelvis and ureter of rats.

Authors:  M Tamaki; T Iwanaga; S Sato; T Fujita
Journal:  Cell Tissue Res       Date:  1992-01       Impact factor: 5.249

6.  Inhibitory transmitter action of calcitonin gene-related peptide in guinea-pig ureter via activation of glibenclamide-sensitive K channels.

Authors:  P Santicioli; C A Maggi
Journal:  Br J Pharmacol       Date:  1994-10       Impact factor: 8.739

7.  Demonstration of the neurotransmitter role of calcitonin gene-related peptides (CGRP) by immunoblockade with anti-CGRP monoclonal antibodies.

Authors:  K K Tan; M J Brown; J Longmore; C Plumpton; R G Hill
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739

Review 8.  Neuropeptide Profiles of Mammalian Male Genital Tract: Distribution and Functional Relevance in Reproduction.

Authors:  Jamiu O Omirinde; Idris A Azeez
Journal:  Front Vet Sci       Date:  2022-03-30
  8 in total

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