Literature DB >> 3263466

Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo.

L Tentori1, D L Longo, J C Zuñiga-Pflucker, C Wing, A M Kruisbeek.   

Abstract

The role of the IL-2-IL-2-R pathway in thymocyte differentiation in vivo is unknown. We have examined fetal thymocyte development in vivo, under conditions where all IL-2-R were saturated from day 13 of gestation with anti-IL-2-R mAbs that were previously shown to render mature T cells unable to respond to IL-2. This produced a dramatic change in the composition of developing T cells: thymocytes from day 1 neonatal mice born to anti-IL-2-R-treated mothers did not contain CD4+ or CD8+ single-positive cell populations. In addition, no generation of surface TCR beta chain-expressing T cells or antigen-reactive functional T cells occurred in treated mice. These data suggest that IL-2-IL-2-R interactions provide signals crucial to in vivo intrathymic development of mature T cells.

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Year:  1988        PMID： 3263466      PMCID： PMC2189119          DOI： 10.1084/jem.168.5.1741

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  17 in total

1.  Proliferation in vitro and interleukin production by 14 day fetal and adult Lyt-2-/L3T4- mouse thymocytes.

Authors:  R Ceredig
Journal:  J Immunol       Date:  1986-10-01       Impact factor: 5.422

2.  A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family.

Authors:  B J Fowlkes; A M Kruisbeek; H Ton-That; M A Weston; J E Coligan; R H Schwartz; D M Pardoll
Journal:  Nature       Date:  1987 Sep 17-23       Impact factor: 49.962

3.  Only high-affinity receptors for interleukin 2 mediate internalization of ligand.

Authors:  A M Weissman; J B Harford; P B Svetlik; W L Leonard; J M Depper; T A Waldmann; W C Greene; R D Klausner
Journal:  Proc Natl Acad Sci U S A       Date:  1986-03       Impact factor: 11.205

4.  The murine IL 2 receptor. I. Monoclonal antibodies that define distinct functional epitopes on activated T cells and react with activated B cells.

Authors:  G Ortega; R J Robb; E M Shevach; T R Malek
Journal:  J Immunol       Date:  1984-10       Impact factor: 5.422

5.  The major histocompatibility complex-restricted antigen receptor on T cells: distribution on thymus and peripheral T cells.

Authors:  N Roehm; L Herron; J Cambier; D DiGuisto; K Haskins; J Kappler; P Marrack
Journal:  Cell       Date:  1984-09       Impact factor: 41.582

6.  Transient expression of IL-2 receptor precedes the differentiation of immature thymocytes.

Authors:  R P Shimonkevitz; L A Husmann; M J Bevan; I N Crispe
Journal:  Nature       Date:  1987 Sep 10-16       Impact factor: 49.962

7.  Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors.

Authors:  E J Jenkinson; R Kingston; J J Owen
Journal:  Nature       Date:  1987 Sep 10-16       Impact factor: 49.962

8.  Proliferation and production of IL-2 and B cell stimulatory factor 1/IL-4 in early fetal thymocytes by activation through Thy-1 and CD3.

Authors:  L Tentori; D M Pardoll; J C Zuñiga; J Hu-Li; W E Paul; J A Bluestone; A M Kruisbeek
Journal:  J Immunol       Date:  1988-02-15       Impact factor: 5.422

9.  Expression and function of interleukin-2 receptors on immature thymocytes.

Authors:  D H Raulet
Journal:  Nature       Date:  1985 Mar 7-13       Impact factor: 49.962

10.  Precursors of T cell growth factor producing cells in the thymus: ontogeny, frequency, and quantitative recovery in a subpopulation of phenotypically mature thymocytes defined by monoclonal antibody GK-1.5.

Authors:  R Ceredig; D P Dialynas; F W Fitch; H R MacDonald
Journal:  J Exp Med       Date:  1983-11-01       Impact factor: 14.307
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  18 in total

1.  Immunosuppression with cyclosporin A alters the thymic microenvironment.

Authors:  M Kanariou; R Huby; H Ladyman; M Colic; G Sivolapenko; I Lampert; M Ritter
Journal:  Clin Exp Immunol       Date:  1989-11       Impact factor: 4.330

2.  Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7.

Authors:  Y W He; R B Levy; T R Malek
Journal:  Proc Natl Acad Sci U S A       Date:  1995-06-06       Impact factor: 11.205

3.  IL-3 and IL-4 affect thymocyte differentiation in organ culture.

Authors:  P M Wood; R K Jordan; A L Givan; C G Brooks
Journal:  Immunology       Date:  1990-09       Impact factor: 7.397

4.  Expression of p55 (Tac) interleukin-2 receptor (IL-2R), but not p75 IL-2R, in cultured H-RS cells and H-RS cells in tissues.

Authors:  S M Hsu; C K Tseng; P L Hsu
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

5.  Phenotypic and functional analysis of positive selection in the gamma/delta T cell lineage.

Authors:  F B Wells; Y Tatsumi; J A Bluestone; S M Hedrick; J P Allison; L A Matis
Journal:  J Exp Med       Date:  1993-04-01       Impact factor: 14.307

6.  Interaction between NF-kappa B- and serum response factor-binding elements activates an interleukin-2 receptor alpha-chain enhancer specifically in T lymphocytes.

Authors:  A A Kuang; K D Novak; S M Kang; K Bruhn; M J Lenardo
Journal:  Mol Cell Biol       Date:  1993-04       Impact factor: 4.272

7.  Requirements for the induction of the interleukin-2 receptor complex in a human pre-T-cell line.

Authors:  P D Salvati; S E Peroni; P R Ranford; U R Kees
Journal:  Immunology       Date:  1993-03       Impact factor: 7.397

8.  IL-2, IL-3, and IFN-gamma differently affect in vivo frequencies of circulating precursors of cytotoxic T lymphocytes (CTL-P).

Authors:  F Hladik; K Kolbe; E U Irschick; M J Aman; G Gerken; L Färber; E Liehl; C Peschel; W E Aulitzky; C Huber
Journal:  Ann Hematol       Date:  1993-08       Impact factor: 3.673

9.  Isolation of proliferation factor of immature T-cell clone in concanavalin A-stimulated splenocyte culture supernatant.

Authors:  Yasuhiro Kohama; Shinji Shinoda; Katsunobu Hagihara; Takeshi Hashimoto; Asuka Yamaguchi; Akihiro Nakamura; Takahiro Tsuchiya; Kazutake Tsujikawa; Hiroshi Yamamoto
Journal:  Immunology       Date:  2003-06       Impact factor: 7.397

10.  Regulation of mu opioid receptor expression in developing T cells.

Authors:  Lily Zhang; Judith Sliker Belkowski; Tammi Briscoe; Thomas J Rogers
Journal:  J Neuroimmune Pharmacol       Date:  2012-08-25       Impact factor: 4.147
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