Literature DB >> 3263317

Application of a human T cell line derived from a Sézary syndrome patient for human interleukin 4 assay.

M Maeda1, T Noma, K Hama, T Honjo.   

Abstract

Interleukin 4 (IL-4) is a multi-functional biological regulator molecule. We developed a simple assay system for human IL-4, using a IL-2-dependent T cell line designated Sez 627 cell line. Sez 627 cells were found to respond only to human IL-4 and human IL-2, but not to other available lymphokines. In combination with mouse IL-2-dependent CTLL-2 cell line, which responds to both human and murine IL-2 but not to human IL-4, human IL-4 activity can be discriminated from human IL-2 activity.

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Year:  1988        PMID： 3263317     DOI： 10.1016/0165-2478(88)90170-8

Source DB:  PubMed          Journal:  Immunol Lett        ISSN： 0165-2478            Impact factor:   3.685


  5 in total

1.  Efficient ex vivo generation of human dendritic cells from mobilized CD34+ peripheral blood progenitors.

Authors:  K Ohishi; N Katayama; H Mitani; H Araki; M Masuya; H Suzuki; N Hoshino; H Miyashita; K Nishii; S Kageyama; N Minami; H Shiku
Journal:  Int J Hematol       Date:  2001-10       Impact factor: 2.490

2.  Interleukin-4 regulates the interleukin-2 receptors on human peripheral blood B lymphocytes.

Authors:  K Tomizawa; A Ishizaka; K Kojima; M Nakanishi; Y Sakiyama; S Matsumoto
Journal:  Clin Exp Immunol       Date:  1991-03       Impact factor: 4.330

3.  Expression of p55 (Tac) interleukin-2 receptor (IL-2R), but not p75 IL-2R, in cultured H-RS cells and H-RS cells in tissues.

Authors:  S M Hsu; C K Tseng; P L Hsu
Journal:  Am J Pathol       Date:  1990-04       Impact factor: 4.307

4.  IL-4 down-regulates the surface expression of CD5 on B cells and inhibits spontaneous immunoglobulin and IgM-rheumatoid factor production in patients with rheumatoid arthritis.

Authors:  T Hidaka; A Kitani; M Hara; M Harigai; K Suzuki; Y Kawaguchi; T Ishizuka; M Kawagoe; H Nakamura
Journal:  Clin Exp Immunol       Date:  1992-08       Impact factor: 4.330

5.  Large-scale culture system of human CD4+ helper/killer T cells for the application to adoptive tumour immunotherapy.

Authors:  Y Nakamura; Y Tokuda; M Iwasawa; H Tsukamoto; M Kidokoro; N Kobayashi; S Kato; T Mitomi; S Habu; T Nishimura
Journal:  Br J Cancer       Date:  1992-07       Impact factor: 7.640
  5 in total

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