Literature DB >> 3263290

Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin.

A Mansouri1, N Spurr, P N Goodfellow, R Kemler.   

Abstract

We have isolated an approximately 2.0-kb human cDNA clone containing coding sequences for the human cell adhesion molecule, uvomorulin. Comparison of human and mouse cDNA revealed extensive homology of 82% for the nucleotide and 83% for the deduced amino acid sequence. This and other structural features common to both cDNAs demonstrate that uvomorulin is evolutionarily highly conserved in mammals and underline its functional importance in histogenesis. Moreover, with the use of human x mouse somatic-cell hybrids, the human uvomorulin gene was localized on chromosome 16, in the region 16p11-16qter.

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Year:  1988        PMID： 3263290     DOI： 10.1111/j.1432-0436.1988.tb00593.x

Source DB:  PubMed          Journal:  Differentiation        ISSN： 0301-4681            Impact factor:   3.880


  30 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
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2.  Cadherins, steroids and cancer.

Authors:  O W Blaschuk; S B Munro; R Farookhi
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Review 3.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 4.  Mouse chromosome 8.

Authors:  J D Ceci
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

Review 5.  Decreased expression of the intercellular adhesion molecule E-cadherin in prostate cancer: biological significance and clinical implications.

Authors:  L A Giroldi; J A Schalken
Journal:  Cancer Metastasis Rev       Date:  1993-03       Impact factor: 9.264

Review 6.  Molecular biology of cadherins in the nervous system.

Authors:  A M Dalseg; H Gaardsvoll; E Bock
Journal:  Mol Neurobiol       Date:  1993 Fall-Winter       Impact factor: 5.590

7.  Genomic structure and chromosomal mapping of the mouse N-cadherin gene.

Authors:  S Miyatani; N G Copeland; D J Gilbert; N A Jenkins; M Takeichi
Journal:  Proc Natl Acad Sci U S A       Date:  1992-09-15       Impact factor: 11.205

Review 8.  Adhesion or anti-adhesion in cancer: what matters more?

Authors:  S Jothy; S B Munro; L LeDuy; D McClure; O W Blaschuk
Journal:  Cancer Metastasis Rev       Date:  1995-12       Impact factor: 9.264

9.  Genomic organization and chromosomal mapping of the mouse P-cadherin gene.

Authors:  M Hatta; S Miyatani; N G Copeland; D J Gilbert; N A Jenkins; M Takeichi
Journal:  Nucleic Acids Res       Date:  1991-08-25       Impact factor: 16.971

10.  The structure of the gene coding for the mouse cell adhesion molecule uvomorulin.

Authors:  M Ringwald; H Baribault; C Schmidt; R Kemler
Journal:  Nucleic Acids Res       Date:  1991-12-11       Impact factor: 16.971
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