Literature DB >> 326325

A comparison of piribedil, procyclidine and placebo in the control of phenothiazine-induced parkinsonism.

R H Mindham, P Lamb, R Bradley.   

Abstract

A double-blind, cross-over trial of the effectiveness of piribedil, procyclidine and placebo in the control of parkinsonism induced by fluphenazine decanoate was conducted in sixteen cases of chronic schizophrenia. Procyclidine was shown to be more effective and piribedil less effective than the placebo. Piribedil produced a number of unpleasant effects, including headache, vomiting and malaise.

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Year:  1977        PMID: 326325     DOI: 10.1192/bjp.130.6.581

Source DB:  PubMed          Journal:  Br J Psychiatry        ISSN: 0007-1250            Impact factor:   9.319


  6 in total

1.  Pharmacokinetics and Pharmacodynamics of procyclidine in man.

Authors:  P D Whiteman; A S Fowle; M J Hamilton; A W Peck; A Bye; K Dean; A Webster
Journal:  Eur J Clin Pharmacol       Date:  1985       Impact factor: 2.953

2.  Isolation and identification of eight procyclidine metabolites from rat urine.

Authors:  G Paeme; R Grimee; A Vercruysse
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1984 Apr-Jun       Impact factor: 2.441

Review 3.  Assessment of extrapyramidal disorders.

Authors:  C D Marsden; M Schachter
Journal:  Br J Clin Pharmacol       Date:  1981-02       Impact factor: 4.335

4.  Effects of mianserin in neuroleptic-induced parkinsonism.

Authors:  S Korsgaard; T Friis
Journal:  Psychopharmacology (Berl)       Date:  1986       Impact factor: 4.530

5.  In vitro metabolism of procyclidine in the rat.

Authors:  G Paeme; R Grimee; A Vercruysse
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1984 Oct-Dec       Impact factor: 2.441

6.  Phenobarbital induction of procyclidine metabolism: in vitro study.

Authors:  G Paeme; H Van Bossuyt; A Vercruysse
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1982       Impact factor: 2.441

  6 in total

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