Huiyuan Hou1, Sasan Moghimi1, Linda M Zangwill1, James A Proudfoot1, Tadamichi Akagi1,2, Takuhei Shoji1,3, Christopher A Girkin4, Jeffrey M Liebmann5, Robert N Weinreb1. 1. Hamilton Glaucoma Center, Shiley Eye Institute, Department of Ophthalmology, University of California San Diego, La Jolla, CA. 2. Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan. 3. Department of Ophthalmology, Saitama Medical University, Saitama, Japan. 4. Department of Ophthalmology, University of Alabama, Birmingham, Alabama. 5. Department of Ophthalmology, New York Eye and Ear Infirmary, New York, New York.
Abstract
Purpose: To compare the rates of retinal nerve fiber layer (RNFL) thinning after intraocular pressure (IOP) lowering procedures in eyes with or without disc hemorrhage (DH) history. Design: Observational cohort study. Methods: A total of 166 primary open angle glaucoma (POAG) eyes and glaucoma suspect eyes (37 eyes with DH history (DH group) and 129 eyes without DH (non-DH group)) were included from the African Decent and Glaucoma Evaluation Study (ADAGES) and the Diagnostic Innovations in Glaucoma Study (DIGS). Subjects underwent stereoscopic optic disc photography annually and spectral-domain optical coherence tomography (OCT) RNFL thickness measurements every 6 months. The rates of RNFL thinning were compared in eyes with and without DH using univariate and multivariable linear mixed effects models. Main Outcome Measures: The rates of RNFL thinning. Results: The mean follow-up of DH group and non-DH group was 4.6 years and 4.2 years, respectively. DH group had more procedures (2.4 vs. 1.9, P= 0.080) before follow-up, and more medications (1.8 vs. 1.4, P= 0.052) and lower mean IOP (12.69 mmHg vs. 14.41 mmHg, P= 0.012) during follow-up compared to non-DH group. When mean IOP was adjusted as a covariate in the model, the RNFL thinning rate in the DH group was 2-fold faster than in the non-DH group (-0.61 μm /year vs. -0.33 μm /year, P= 0.025). Higher mean IOP during follow-up was associated with a faster rate of RNFL thinning after procedures. Conclusions: POAG or glaucoma suspect eyes with a history of DH should be carefully followed after IOP-lowering procedures. Additional IOP-lowering may be needed to slow structural progression of the DH eyes to the same rate as the non-DH eyes.
Purpose: To compare the rates of retinal nerve fiber layer (RNFL) thinning after intraocular pressure (IOP) lowering procedures in eyes with or without disc hemorrhage (DH) history. Design: Observational cohort study. Methods: A total of 166 primary open angle glaucoma (POAG) eyes and glaucoma suspect eyes (37 eyes with DH history (DH group) and 129 eyes without DH (non-DH group)) were included from the African Decent and Glaucoma Evaluation Study (ADAGES) and the Diagnostic Innovations in Glaucoma Study (DIGS). Subjects underwent stereoscopic optic disc photography annually and spectral-domain optical coherence tomography (OCT) RNFL thickness measurements every 6 months. The rates of RNFL thinning were compared in eyes with and without DH using univariate and multivariable linear mixed effects models. Main Outcome Measures: The rates of RNFL thinning. Results: The mean follow-up of DH group and non-DH group was 4.6 years and 4.2 years, respectively. DH group had more procedures (2.4 vs. 1.9, P= 0.080) before follow-up, and more medications (1.8 vs. 1.4, P= 0.052) and lower mean IOP (12.69 mmHg vs. 14.41 mmHg, P= 0.012) during follow-up compared to non-DH group. When mean IOP was adjusted as a covariate in the model, the RNFL thinning rate in the DH group was 2-fold faster than in the non-DH group (-0.61 μm /year vs. -0.33 μm /year, P= 0.025). Higher mean IOP during follow-up was associated with a faster rate of RNFL thinning after procedures. Conclusions: POAG or glaucoma suspect eyes with a history of DH should be carefully followed after IOP-lowering procedures. Additional IOP-lowering may be needed to slow structural progression of the DH eyes to the same rate as the non-DH eyes.
Authors: Christopher K S Leung; Cong Ye; Robert N Weinreb; Marco Yu; Gilda Lai; Dennis S Lam Journal: Ophthalmology Date: 2013-08-30 Impact factor: 12.079
Authors: Christopher K S Leung; Marco Yu; Robert N Weinreb; Cong Ye; Shu Liu; Gilda Lai; Dennis S C Lam Journal: Ophthalmology Date: 2012-01-20 Impact factor: 12.079
Authors: Heather C de Beaufort; Carlos Gustavo V De Moraes; Christopher C Teng; Tiago S Prata; Celso Tello; Robert Ritch; Jeffrey M Liebmann Journal: Graefes Arch Clin Exp Ophthalmol Date: 2010-02-25 Impact factor: 3.117
Authors: Alberto Diniz-Filho; Ricardo Y Abe; Linda M Zangwill; Carolina P B Gracitelli; Robert N Weinreb; Christopher A Girkin; Jeffrey M Liebmann; Felipe A Medeiros Journal: Ophthalmology Date: 2016-08-20 Impact factor: 12.079
Authors: Atsuya Miki; Felipe A Medeiros; Robert N Weinreb; Sonia Jain; Feng He; Lucie Sharpsten; Naira Khachatryan; Na'ama Hammel; Jeffrey M Liebmann; Christopher A Girkin; Pamela A Sample; Linda M Zangwill Journal: Ophthalmology Date: 2014-03-13 Impact factor: 12.079
Authors: Carolina A Chiou; Mengyu Wang; Elise V Taniguchi; Rafaella Nascimento E Silva; Anna Khoroshilov; Dian Li; Haobing Wang; Scott H Greenstein; Stacey C Brauner; Angela V Turalba; Louis R Pasquale; Lucy Q Shen Journal: Curr Eye Res Date: 2020-10-27 Impact factor: 2.555