Literature DB >> 3263230

Analysis of CD4-positive T cell subpopulation in sarcoidosis.

R Gerli1, S Darwish, L Broccucci, V Minotti, F Spinozzi, C Cernetti, A Bertotto, P Rambotti.   

Abstract

Double-labelling immunofluorescence analysis within the CD4+ cell subset was carried out in 27 bronchoalveolar lavage fluids and 11 peripheral blood samples of sarcoidosis patients with anti-TQ1, anti-2H4 and anti-4B4 monoclonal antibodies. Helper/inducer CD4+TQ1-/4B4+ cells were strongly increased in the lung and slightly, but significantly, decreased in the blood of sarcoidosis patients with respect to normal controls. No differences were found in the number of both lung and blood CD4+2H4+ cells between sarcoidosis patients and controls. The findings are further evidence for a compartmentalization of T cell subsets in sarcoidosis.

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Year:  1988        PMID： 3263230      PMCID： PMC1541616     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  19 in total

1.  The isolation and characterization of the human helper inducer T cell subset.

Authors:  C Morimoto; N L Letvin; A W Boyd; M Hagan; H M Brown; M M Kornacki; S F Schlossman
Journal:  J Immunol       Date:  1985-06       Impact factor: 5.422

2.  Alveolar lymphocyte activation during sarcoidosis.

Authors:  G Cordier; J Brune; J P Revillard
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

Review 3.  Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings.

Authors:  E L Reinherz; S F Schlossman
Journal:  N Engl J Med       Date:  1980-08-14       Impact factor: 91.245

4.  Heterogeneity of human T4+ inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations.

Authors:  E L Reinherz; C Morimoto; K A Fitzgerald; R E Hussey; J F Daley; S F Schlossman
Journal:  J Immunol       Date:  1982-01       Impact factor: 5.422

5.  The alveolitis of pulmonary sarcoidosis. Evaluation of natural history and alveolitis-dependent changes in lung function.

Authors:  B A Keogh; G W Hunninghake; B R Line; R G Crystal
Journal:  Am Rev Respir Dis       Date:  1983-08

6.  T-lymphocyte subsets and immunoglobulin concentrations in bronchoalveolar lavage of patients with sarcoidosis and high and low intensity alveolitis.

Authors:  W Bauer; M K Gorny; H R Baumann; A Morell
Journal:  Am Rev Respir Dis       Date:  1985-11

7.  The isolation and characterization of the human suppressor inducer T cell subset.

Authors:  C Morimoto; N L Letvin; J A Distaso; W R Aldrich; S F Schlossman
Journal:  J Immunol       Date:  1985-03       Impact factor: 5.422

8.  Lack of immune deficiency in sarcoidosis: compartmentalisation of the immune response.

Authors:  B N Hudspith; K C Flint; D Geraint-James; J Brostoff; N M Johnson
Journal:  Thorax       Date:  1987-04       Impact factor: 9.139

9.  Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity.

Authors:  G W Hunninghake; R G Crystal
Journal:  N Engl J Med       Date:  1981-08-20       Impact factor: 91.245

10.  Helper T-lymphocytes in pulmonary sarcoidosis. Functional analysis of a lung T-cell subpopulation in patients with active disease.

Authors:  G A Rossi; O Sacco; E Cosulich; A Risso; B Balbi; C Ravazzoni
Journal:  Am Rev Respir Dis       Date:  1986-06
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  5 in total

1.  Basis for defective proliferation of peripheral blood T cells to anti-CD2 antibodies in primary Sjögren's syndrome.

Authors:  R Gerli; A Bertotto; E Agea; L Lanfrancone; C Cernetti; F Spinozzi; P Rambotti
Journal:  J Clin Invest       Date:  1990-12       Impact factor: 14.808

2.  Expression of surface antigens distinguishing "naive" and previously activated lymphocytes in bronchoalveolar lavage fluid.

Authors:  S Dominique; F Bouchonnet; J M Smiéjan; A J Hance
Journal:  Thorax       Date:  1990-05       Impact factor: 9.139

3.  Analysis of T cell subsets and beta chemokines in patients with pulmonary sarcoidosis.

Authors:  K Iida; J Kadota; K Kawakami; Y Matsubara; R Shirai; S Kohno
Journal:  Thorax       Date:  1997-05       Impact factor: 9.139

4.  Detection of endogenous cytokines in sera or in lymph nodes obtained from patients with sarcoidosis.

Authors:  M Asano; T Minagawa; M Ohmichi; Y Hiraga
Journal:  Clin Exp Immunol       Date:  1991-04       Impact factor: 4.330

5.  Analysis of Clinical Factors Associated with Retinal Morphological Changes in Patients with Primary Sjögren's Syndrome.

Authors:  Jee Myung Yang; Mi Sun Sung; Yong Sok Ji; Hwan Heo; Sang Woo Park
Journal:  PLoS One       Date:  2016-06-21       Impact factor: 3.240
  5 in total

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