Literature DB >> 32631825

Characterization of Large Deletion Mutants of Mycobacterium tuberculosis Selected for Isoniazid Resistance.

Catherine Vilchèze1, Rajagopalan Saranathan1, Brian Weinrick1, William R Jacobs2.   

Abstract

Large genomic deletions (LGDs) (6 to 63 kbp) were observed in isoniazid-resistant Mycobacterium tuberculosis mutants derived from four M. tuberculosis strains. These LGDs had no growth defect in vitro but could be defective in intracellular growth and showed various sensitivities toward oxidative stress despite lacking katG The LGD regions comprise 74 genes, mostly of unknown function, that may be important for M. tuberculosis intracellular growth and protection against oxidative stress.
Copyright © 2020 American Society for Microbiology.

Entities:  

Keywords:  arginine; deletion; isoniazid; resistance

Mesh：

Substances：

Year:  2020        PMID： 32631825      PMCID： PMC7449219          DOI： 10.1128/AAC.00792-20

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  13 in total

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4.  Enhanced respiration prevents drug tolerance and drug resistance in Mycobacterium tuberculosis.

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5.  Arginine-deprivation-induced oxidative damage sterilizes Mycobacterium tuberculosis.

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6.  L-arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes.

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Journal:  Proc Natl Acad Sci U S A       Date:  2018-01-30       Impact factor: 11.205

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9.  The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.

Authors:  Y Zhang; B Heym; B Allen; D Young; S Cole
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10.  Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy.

Authors:  Catherine Vilchèze; Jacqueline Copeland; Tracy L Keiser; Torin Weisbrod; Jacqueline Washington; Paras Jain; Adel Malek; Brian Weinrick; William R Jacobs
Journal:  mBio       Date:  2018-05-29       Impact factor: 7.867
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