Hee Kong Fong1, Rupak Desai2, Mohammed Faisaluddin3, Tarang Parekh4, Ahmed Mahmood5, Vraj Shah6, Priyal Shah7, Vaishnavi Reddy Varakantam8, Falah Abu Hassan9, Sejal Savani10, Rajkumar Doshi11, Kishorbhai Gangani12. 1. Division of Cardiovascular Medicine, UC Davis Medical Center, Sacramento, CA, USA. 2. Division of Cardiology, Atlanta VA Medical Center, Decatur, GA, USA. Electronic address: drrupakdesai@gmail.com. 3. Department of Medicine, Deccan College of Medical Sciences, Hyderabad, India. 4. Department of Health Administration and Policy, George Mason University, Fairfax, VA, USA. 5. Department of Internal Medicine, Eastern Idaho Regional Medical Center, Idaho Falls, ID, USA. 6. Division of cardiology, Medical College Baroda, Vadodara, Gujarat, India. 7. Department of Medicine, GMERS Medical College and General Hospital, Gotri, Vadodara, India. 8. Department of Medicine, Medi Citi Institute of Medical Sciences, Medchal Mandal, Ghanapur, Telangana, India. 9. Department of General Surgery, Princess of Wales hospital, Bridgend, CF31 1RQ, UK. 10. Public Health, New York University, New York, New York, USA. 11. Department of Internal Medicine, University of Nevada Reno School of Medicine, Reno, NV, USA. 12. Department of Internal Medicine, Texas Health Arlington Memorial Hospital, Arlington, TX, USA.
Abstract
AIMS: To analyze the sex-based differences in the prevalence of cardiovascular disease risk factors and outcomes in older patients with prediabetes using demographically matched national cohorts of hospitalized patients aged ≥65 years. METHODS: We queried the 2007-2014 National Inpatient Database to identify older patients (>65 years) admitted with prediabetes using ICD-9 Clinical Modification codes. The older patients were then subcategorized based on sex. Comparative analyses of their baseline characteristics, the prevalence of cardiovascular(CV) disease comorbidities, hospitalization outcomes, and mortality rates were performed on propensity-matched cohorts for demographics. RESULTS: A total of 1,197,978 older patients with prediabetes (599,223 males; mean age 75years and 598,755 females; mean age 76years) were identified. Higher admission rates were found commonly among older white males (84.1%) and females (81.7%). Prediabetic older males showed a higher frequency of cardiovascular comorbidities compared to females. Prediabetic older males had higher all-cause in-hospital mortality (4.2% vs. 3.6%, p < 0.001), acute myocardial infarction (7.0% vs. 4.7%, p < 0.001), arrhythmia (36.3% vs. 30.5%, p < 0.001), stroke (4.8% vs. 4.6%, p < 0.001), venous thromboembolism (3.3% vs. 3.0%, p < 0.001) and percutaneous coronary intervention (3.1% vs. 1.5%, p < 0.001) compared to females. CONCLUSIONS: Our analysis revealed that among older patients hospitalized with prediabetes, males suffered worse in-hospital CV outcomes and survival rates compared to females.
AIMS: To analyze the sex-based differences in the prevalence of cardiovascular disease risk factors and outcomes in older patients with prediabetes using demographically matched national cohorts of hospitalized patients aged ≥65 years. METHODS: We queried the 2007-2014 National Inpatient Database to identify older patients (>65 years) admitted with prediabetes using ICD-9 Clinical Modification codes. The older patients were then subcategorized based on sex. Comparative analyses of their baseline characteristics, the prevalence of cardiovascular(CV) disease comorbidities, hospitalization outcomes, and mortality rates were performed on propensity-matched cohorts for demographics. RESULTS: A total of 1,197,978 older patients with prediabetes (599,223 males; mean age 75years and 598,755 females; mean age 76years) were identified. Higher admission rates were found commonly among older white males (84.1%) and females (81.7%). Prediabetic older males showed a higher frequency of cardiovascular comorbidities compared to females. Prediabetic older males had higher all-cause in-hospital mortality (4.2% vs. 3.6%, p < 0.001), acute myocardial infarction (7.0% vs. 4.7%, p < 0.001), arrhythmia (36.3% vs. 30.5%, p < 0.001), stroke (4.8% vs. 4.6%, p < 0.001), venous thromboembolism (3.3% vs. 3.0%, p < 0.001) and percutaneous coronary intervention (3.1% vs. 1.5%, p < 0.001) compared to females. CONCLUSIONS: Our analysis revealed that among older patients hospitalized with prediabetes, males suffered worse in-hospital CV outcomes and survival rates compared to females.