Literature DB >> 3263134

Effects of recombinant human interleukin-1 beta on rabbit articular chondrocytes. Stimulation of prostanoid release and inhibition of cell growth.

J E Chin1, Y A Lin.   

Abstract

Using an in vitro model, we characterized the production of prostaglandin E2, 6-keto-prostaglandin F1 alpha, and thromboxane B2 by normal rabbit articular chondrocytes stimulated by interleukin-1 beta. The prostanoids were produced in a dose- and time-dependent manner, which was sensitive to actinomycin D and cycloheximide. Interleukin-1 also had a pronounced, but reversible, cytostatic effect on chondrocytes, which was not attributable to prostanoid or polyamine synthesis.

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Year:  1988        PMID： 3263134     DOI： 10.1002/art.1780311011

Source DB:  PubMed          Journal:  Arthritis Rheum        ISSN： 0004-3591


  8 in total

1.  Effects of recombinant human IL-1 beta on production of prostaglandin E2, leukotriene B4, NAG, and superoxide by human synovial cells and chondrocytes.

Authors:  T Tawara; M Shingu; M Nobunaga; T Naono
Journal:  Inflammation       Date:  1991-04       Impact factor: 4.092

2.  Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes.

Authors:  Y E Henrotin; A H Labasse; J M Jaspar; D D De Groote; S X Zheng; G B Guillou; J Y Reginster
Journal:  Clin Rheumatol       Date:  1998       Impact factor: 2.980

3.  An aggrecan-degrading activity associated with chondrocyte membranes.

Authors:  C J Billington; I M Clark; T E Cawston
Journal:  Biochem J       Date:  1998-11-15       Impact factor: 3.857

4.  Effects of the cytokines on the proliferation of and collagen synthesis by human cataract lens epithelial cells.

Authors:  O Nishi; K Nishi; T Fujiwara; E Shirasawa; Y Ohmoto
Journal:  Br J Ophthalmol       Date:  1996-01       Impact factor: 4.638

5.  Chondrotoxicity of quinolones in vivo and in vitro.

Authors:  H Hildebrand; G Kempka; G Schlüter; M Schmidt
Journal:  Arch Toxicol       Date:  1993       Impact factor: 5.153

6.  Cytokine enhancement of monocyte/synovial cell attachment to the surface of cartilage: a possible trigger of pannus formation in arthritis.

Authors:  H Ishikawa; O Ohno; R Saura; T Matsubara; T Kuroda; K Hirohata
Journal:  Rheumatol Int       Date:  1991       Impact factor: 2.631

7.  Hyperphospholipasemia A2 in human volunteers challenged with intravenous endotoxin.

Authors:  W Pruzanski; D W Wilmore; A Suffredini; G D Martich; A G Hoffman; J L Browning; E Stefanski; B Sternby; P Vadas
Journal:  Inflammation       Date:  1992-10       Impact factor: 4.092

8.  Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.

Authors:  J C Beckham; D S Caldwell; B L Peterson; A M Pippen; M S Currie; F J Keefe; J B Weinberg
Journal:  J Clin Immunol       Date:  1992-09       Impact factor: 8.317
  8 in total

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