Augmentation and stable expression of a novel transcription factor SII in CD4-positive cells on infection with human immunodeficiency virus type-1 (HIV-1).

We have examined the expression of a novel transcription factor SII in HIV-infected cells. Concomitant with the increasing expression of HIV-1 mRNA, the viability of HIV infected cells dropped and the expression of beta-actin gene also diminished. Concurrently, the expression of SII mRNA was stabilized or augmented. The data presented in this communication suggests that in HIV-1 infected cells, selective transcriptional controls were taking place and that a novel transcriptional factor, SII, plays an essential role in HIV-1 expression leading to cytocidal effects.