Literature DB >> 32630183

LncRNA NEAT1 in Paraspeckles: A Structural Scaffold for Cellular DNA Damage Response Systems?

Elisa Taiana1,2, Domenica Ronchetti1,2, Katia Todoerti2, Lucia Nobili1, Pierfrancesco Tassone3, Nicola Amodio3, Antonino Neri1,2.   

Abstract

Nuclear paraspeckle assembly transcript 1 (NEAT1) is a long non-coding RNA (lncRNA) reported to be frequently deregulated in various types of cancers and neurodegenerative processes. NEAT1 is an indispensable structural component of paraspeckles (PSs), which are dynamic and membraneless nuclear bodies that affect different cellular functions, including stress response. Furthermore, increasing evidence supports the crucial role of NEAT1 and essential structural proteins of PSs (PSPs) in the regulation of the DNA damage repair (DDR) system. This review aims to provide an overview of the current knowledge on the involvement of NEAT1 and PSPs in DDR, which might strengthen the rationale underlying future NEAT1-based therapeutic options in tumor and neurodegenerative diseases.

Entities:  

Keywords:  DNA damage repair; NEAT1; cancer; lncRNA; neurodegenerative disease; paraspeckle

Year:  2020        PMID： 32630183     DOI： 10.3390/ncrna6030026

Source DB:  PubMed          Journal:  Noncoding RNA        ISSN： 2311-553X


  6 in total

1.  Secondhand smoke affects reproductive functions by altering the mouse testis transcriptome, and leads to select intron retention in Pde1a.

Authors:  Stella Tommasi; Tevfik H Kitapci; Hannah Blumenfeld; Ahmad Besaratinia
Journal:  Environ Int       Date:  2022-01-18       Impact factor: 9.621

Review 2.  Role of Liquid-Liquid Separation in Endocrine and Living Cells.

Authors:  Kazuhisa Akiba; Yuko Katoh-Fukui; Kei Yoshida; Satoshi Narumi; Mami Miyado; Yukihiro Hasegawa; Maki Fukami
Journal:  J Endocr Soc       Date:  2021-07-19

3.  DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0.

Authors:  Yun-Long Wang; Wan-Wen Zhao; Shao-Mei Bai; Yan Ma; Xin-Ke Yin; Li-Li Feng; Guang-Dong Zeng; Fang Wang; Wei-Xing Feng; Jian Zheng; Ying-Nai Wang; Bing Zeng; Quentin Liu; Mien-Chie Hung; Xiang-Bo Wan
Journal:  Cell Death Dis       Date:  2022-08-16       Impact factor: 9.685

Review 4.  Exploring the Roles of lncRNAs in GBM Pathophysiology and Their Therapeutic Potential.

Authors:  Christian T Stackhouse; G Yancey Gillespie; Christopher D Willey
Journal:  Cells       Date:  2020-10-28       Impact factor: 6.600

Review 5.  Differential Allelic Expression among Long Non-Coding RNAs.

Authors:  Michael B Heskett; Paul T Spellman; Mathew J Thayer
Journal:  Noncoding RNA       Date:  2021-10-22

Review 6.  Novel Insights into the Emerging Role of Neat1 and Its Effects Downstream in the Regulation of Inflammation.

Authors:  Yongli Pan; Ting Wang; Zhiqiang Zhao; Wei Wei; Xinyu Yang; Xianbin Wang; Wenqiang Xin
Journal:  J Inflamm Res       Date:  2022-01-26
  6 in total

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