| Literature DB >> 32628985 |
Cong Su1, Yangyang Duan1, Jinying Tian1, Jimei Liu1, Kebo Xie1, Dawei Chen1, Fei Ye1, Ridao Chen2, Jungui Dai3.
Abstract
Six new Diels-Alder type adducts, morusalisins A-F (1-6), were isolated from Morus alba cell cultures. The structures of 1-6 were determined by extensive spectroscopic data analysis, including HRESIMS, NMR, and ECD experiments. Furthermore, compounds 1-6 exhibited potent protein tyrosine phosphatase 1B (PTP1B) inhibitory activity with IC50 values ranging from 1.14 to 2.24 μM, making them promising as bioactive compounds for anti-diabetic drug discovery.Entities:
Keywords: Diels-Alder adducts; Morus alba; Morusalisin; PTP1B inhibitory activity
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Year: 2020 PMID： 32628985 DOI： 10.1016/j.fitote.2020.104682
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882