| Literature DB >> 32628027 |
Kyuho Moon1,2, Jinsheng Cui1, Eunji Kim1, Evan Setiawan Riandi1, So Hyun Park1, Woong Sub Byun1, Youngju Kal3, Jun Young Park3, Sunghoon Hwang1, Daniel Shin1, Jeongyoon Sun4, Ki-Bong Oh4, Sangwon Cha3, Jongheon Shin1, Sang Kook Lee1, Yeo Joon Yoon1, Dong-Chan Oh1.
Abstract
Pulvomycins B-D (1-3) were discovered from an estuarine Streptomyces strain along with the known pulvomycin (4). The 22-membered macrocyclic lactone structures of 1-3 were determined based on the interpretation of NMR, UV, and MS data, the modified Mosher's method, and Kishi's bidentate chiral solvent NMR spectroscopy. Genomic analysis of the bacterial strain revealed the biosynthetic gene cluster of pulvomycin and enabled us to propose the trans-acyltransferase polyketide biosynthetic pathway. Pulvomycin D displayed potent cytotoxic activity against various cancer cell lines.Entities:
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Year: 2020 PMID： 32628027 DOI： 10.1021/acs.orglett.0c01249
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005