| Literature DB >> 32625958 |
Antonia Ricci, Ana Allende, Declan Bolton, Marianne Chemaly, Robert Davies, Pablo Salvador Fernández Escámez, Rosina Girones, Konstantinos Koutsoumanis, Roland Lindqvist, Birgit Nørrung, Lucy Robertson, Giuseppe Ru, Moez Sanaa, Marion Simmons, Panagiotis Skandamis, Emma Snary, Niko Speybroeck, Benno Ter Kuile, John Threlfall, Helene Wahlström, Pier Sandro Cocconcelli, Luisa Peixe, Miguel Prieto Maradona, Amparo Querol, Juan Evaristo Suarez, Ingvar Sundh, Just Vlak, Fulvio Barizzone, Sandra Correia, Lieve Herman.
Abstract
The qualified presumption of safety (QPS) was developed to provide a harmonised generic pre-evaluation procedure to support safety risk assessments of biological agents performed by EFSA's Scientific Panels. The identity, body of knowledge, safety concerns and antimicrobial resistance of valid taxonomic units were assessed. Safety concerns identified for a taxonomic unit are, where possible and reasonable in number, reflected by 'qualifications' which should be assessed at the strain level by the EFSA's Scientific Panels. During the current assessment, no new information was found that would change the previously recommended QPS taxonomic units and their qualifications. The Panel clarified that the qualification 'for production purpose only' implies the absence of viable cells of the production organism in the final product and can also be applied for food and feed products based on microbial biomass. Between September 2017 and March 2018, the QPS notification list was updated with 46 microorganisms from applications for market authorisation. From these, 28 biological agents already had QPS status, 15 were excluded of the QPS exercise from the previous QPS mandate (10 filamentous fungi and one bacteriophage) or from further evaluations within the current mandate (two notifications of Streptomyces spp. and one of Escherichia coli), and one was excluded where confirmatory data for the risk assessment of a plant protection product (PPP) was requested (Pseudomonas sp.). Three taxonomic units were (re)evaluated: Paracoccus carotinifaciens and Paenibacillus lentus had been previously evaluated in 2008 and 2014, respectively, and were now re-evaluated within this mandate, and Yarrowia lipolytica, which was evaluated for the first time. P. carotinifaciens and P. lentus cannot be granted QPS status due to lack of scientific knowledge. Y. lipolytica is recommended for QPS status, but only for production purpose.Entities:
Keywords: Paenibacillus lentus; Paracoccus carotinifaciens; QPS; Yarrowia lipolytica; bacteria; safety; yeast
Year: 2018 PMID： 32625958 PMCID： PMC7009647 DOI： 10.2903/j.efsa.2018.5315
Source DB: PubMed Journal: EFSA J ISSN： 1831-4732
Notifications received by EFSA, per risk assessment area and by biological group, from September of 2017 to March 2018
| Risk assessment area | Not evaluated in this Statement | Evaluated in this Statement | Total | |
|---|---|---|---|---|
| Biological group | Already QPS | Excluded in QPS | ||
|
|
|
|
|
|
| Bacteria | 21 | 2 | 2 | 25 |
| Filamentous fungi | 0 | 6 | 0 | 6 |
| Yeasts | 2 | 0 | 0 | 2 |
| Bacteriophages | 0 | 1 | 0 | 1 |
|
|
|
|
|
|
| Yeasts | 0 | 0 | 1 | 1 |
|
|
|
|
|
|
| Bacteria | 2 | 1 | 0 | 3 |
| Filamentous fungi | 0 | 3 | 0 | 3 |
| Viruses | 1 | 0 | 0 | 1 |
|
|
|
|
|
|
| Bacteria | 1 | 1 | 0 | 2 |
| Filamentous fungi | 0 | 1 | 0 | 1 |
| Yeasts | 1 | 0 | 0 | 1 |
|
|
|
|
|
|
QPS: qualified presumption of safety.
The number includes filamentous fungi or enterococci excluded from QPS evaluation in the 2013 QPS Opinion, other bacterial species (E. coli, Streptomyces spp.) already excluded in the Panel Statement adopted in June 2017 (EFSA BIOHAZ Panel, 2017b) and also to a notification corresponding to a request on confirmatory data for the risk assessment of a plant protection product (PPP).
Flow of records by search strategy
| Species | No papers (title screening) | No papers (title/abstract screening) | No papers (article appraisal) | No papers (relevant for QPS) |
|---|---|---|---|---|
| Alphaflexiviridae and Potyviridae | 28 | 0 | 0 | 0 |
|
| 1,107 | 16 | 8 | 5 |
| Baculoviridae | 70 | 5 | 3 | 0 |
|
| 204 | 11 | 2 | 0 |
|
| 0 | 0 | ||
|
| 42 | 3 | 0 | 0 |
|
| 155 | 1 | 0 | 0 |
|
| 0 | 0 | ||
|
| 565 | 14 | 6 | 6 |
|
| 152 | 3 | 2 | 0 |
|
| 62 | 8 | 5 | 4 |
|
| 0 | 0 | ||
|
| 37 | 0 | 0 | 0 |
|
| 0 | 0 | ||
|
| 137 | 4 | 3 | 0 |
|
| 49 | 1 | 0 | 0 |
|
| 82 | 4 | 3 | 1 |
| Yeasts | 1,500 | 72 | 52 | 31 |
|
| 4,190 | 142 |
|
|
| Excluded |
|
|
QPS: qualified presumption of safety.
Eligibility criteria for questions 1 and 2
| Criteria | |
|---|---|
| Study design | No specific type of study design will be used to include/exclude relevant studies, although it is expected that the prevalent study designs will be case reports or case series and studies based on surveys or isolate collections |
| Study characteristics: | No exclusion will be based on study characteristics |
| Population | Humans, animals, plants, environment |
| Exposure | Studies must report on at least one TU as identified in Section |
| Outcome of interest | Outcomes as listed in Section |
| Language | English |
| Time | From June 2016 until end June 2019 |
| Publication type | Primary research studies and secondary studies reporting previously unpublished primary studies |
Information sources to be searched to identify relevant studies
| Information source | Interface |
|---|---|
| Web of Science Core Collection | Web of Science, Thomson Reuters 2017 |
| CAB Abstracts | Web of Science, Thomson Reuters 2017 |
| BIOSIS Citation Index | Web of Science, Thomson Reuters 2017 |
| MEDLINE | Web of Science, Thomson Reuters 2017 |
| Food Science Technology Abstracts (FSTA) | Web of Science, Thomson Reuters 2017 |
|
| |
|---|---|
| “Bifidobacterium adolescentis” OR “Bifidobacterium animalis” OR “Bifidobacterium bifidum” OR “Bifidobacterium breve” OR “Bifidobacterium longum” OR “B adolescentis” OR “B animalis” OR “B bifidum” OR “B breve” OR “B longum” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” |
| 3. Type of disease | “endocarditis” OR “abscess” OR “meningitis” |
| 4. Mortality/Morbidity | “clinical*” OR “death*” OR “morbidit*” OR “mortalit*” OR “disease*” OR “illness*” |
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Carnobacterium divergens” OR “C divergens” | |
|
|
|
| 6. Antimicrobial/Antibiotic/Antimycotic |
|
| 7. Infection/Bacteremia/Fungemia/Sepsis |
|
| 8. Type of disease |
|
| 9. Mortality/Morbidity |
|
| 10. Disease Risk |
|
|
| |
|---|---|
| “Corynebacterium glutamicum” OR “C glutamicum” OR “Brevibacterium lactofermentum” OR “B lactofermentum” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” OR “pathogen*” |
| 3. Type of disease |
|
| 4. Mortality/Morbidity | “clinical*” OR “death*” OR “morbidit*” OR “mortalit*” OR “disease*” OR “illness*” |
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Lactobacillus acidophilus” OR “Lactobacillus amylolyticus” OR “Lactobacillus amylovorus” OR “Lactobacillus alimentarius” OR “Lactobacillus animalis” OR “Lactobacillus aviaries” OR “Lactobacillus brevis” OR “Lactobacillus buchneri” OR “Lactobacillus casei” OR “Lactobacillus zeae” OR “Lactobacillus cellobiosus” OR “Lactobacillus coryniformis” OR “Lactobacillus crispatus” OR “Lactobacillus curvatus” OR “Lactobacillus delbrueckii” OR “Lactobacillus diolivorans” OR “Lactobacillus farciminis” OR “Lactobacillus fermentum” OR “Lactobacillus gallinarum” OR “Lactobacillus gasseri” OR “Lactobacillus helveticus” OR “Lactobacillus hilgardii” OR “Lactobacillus johnsonii” OR “Lactobacillus kefiranofaciens” OR “Lactobacillus kefiri” OR “Lactobacillus mucosae” OR “Lactobacillus panis” OR “Lactobacillus collinoides” OR “Lactobacillus paracasei” OR “Lactobacillus paraplantarum” OR “Lactobacillus pentosus” OR “Lactobacillus plantarum” OR “Lactobacillus pontis” OR “Lactobacillus reuteri” OR “Lactobacillus rhamnosus” OR “Lactobacillus sakei” OR “Lactobacillus salivarius” OR “Lactobacillus sanfranciscensis” OR “L acidophilus” OR “L amylolyticus” OR “L amylovorus” OR “L alimentarius” OR “L animalis” OR “L aviaries” OR “L brevis” OR “L buchneri” OR “L casei” OR “L zeae” OR “L cellobiosus” OR “L coryniformis” OR “L crispatus” OR “L curvatus” OR “L delbrueckii” OR “L diolivorans” OR “L farciminis” OR “L fermentum” OR “L gallinarum” OR “L gasseri” OR “L helveticus” OR “L hilgardii” OR “L johnsonii” OR “L kefiranofaciens” OR “L kefiri” OR “L mucosae” OR “L panis” OR “L collinoides” OR “L paracasei” OR “L paraplantarum” OR “L pentosus” OR “L plantarum” OR “L pontis” OR “L reuteri” OR “L rhamnosus” OR “L sakei” OR “L salivarius” OR “L sanfranciscensis” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” |
| 3. Type of disease | “endocarditis” OR “abscess” OR “meningitis” |
| 4. Mortality/Morbidity |
|
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Lactococcus lactis” OR “L lactis” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” |
| 3. Type of disease | “endocarditis” OR “abscess” OR “meningitis” |
| 4. Mortality/Morbidity | “clinical*” OR “death*” OR “morbidit*” OR “mortalit*” OR “disease*” OR “illness*” |
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Leuconostoc mesenteroides” OR “Leuconostoc lactis” OR “Leuconostoc pseudomesenteroides” OR “Leuconostoc citreum” OR “L mesenteroides” OR “L lactis” OR “L pseudomesenteroides” OR “L citreum” | |
|
|
|
| 1. Antmicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” |
| 3. Type of disease |
|
| 4. Mortality/Morbidity | “clinical*” OR “death*” OR “morbidit*” OR “mortalit*” OR “disease*” OR “illness*” |
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Microbacterium imperiale” OR “M imperiale” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
| “Oenococcus oeni” OR “O oeni” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
| “Pasteuria nishizawae” OR “P nishizawae” | |
|
|
|
| 11. Antimicrobial/Antibiotic/Antimycotic |
|
| 12. Infection/Bacteremia/Fungemia/Sepsis |
|
| 13. Type of disease |
|
| 14. Mortality/Morbidity |
|
| 15. Disease Risk |
|
|
| |
|---|---|
| “Pediococcus pentosaceus” OR “Pediococcus dextrinicus” OR “Pediococcus acidilactici” OR “Pediococcus parvulus” OR “P pentosaceus” OR “P dextrinicus” OR “P acidilactici” OR “P parvulus” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
| “Propionibacterium acidipropionici” OR “Propionibacterium freudenreichii” OR “P acidipropionici” OR “P freudenreichii” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
| “Streptococcus thermophilus” OR “S thermophilus”“Streptococcus thermophilus” OR “S thermophilus” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” |
| 3. Type of disease |
|
| 4. Mortality/Morbidity | “clinical*” OR “death*” OR “morbidit*” OR “mortalit*” OR “disease*” OR “illness*” |
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Bacillus amyloliquefaciens” OR “Bacillus coagulans” OR “Bacillus clausii” OR “Bacillus atrophaeus” OR “Bacillus flexus” OR “Bacillus fusiformis” OR “Lysinibacillus fusiformis” OR “Bacillus licheniformis” OR “Bacillus lentus” OR “Bacillus mojavensis” OR “Bacillus megaterium” OR “Bacillus vallismortis” OR “Bacillus smithii” OR “Bacillus subtilis” OR “Bacillus pumilus” OR “Geobacillus stearothermophilus” OR “B amyloliquefaciens” OR “B coagulans” OR “B clausii” OR “B atrophaeus” OR “B flexus” OR “B fusiformis” OR “L fusiformis” OR “B licheniformis” OR “B lentus” OR “B mojavensis” OR “B megaterium” OR “B vallismortis” OR “B smithii” OR “B subtilis” OR “B pumilus” OR “G stearothermophilus” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antibiotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “bacteremia” OR “bacteraemia” OR “toxin*” |
| 3. Type of disease | “endocarditis” OR “abscess” OR “meningitis” |
| 4. Mortality/Morbidity |
|
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
|
| |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
| “Xanthomonas campestris” OR “X campestris” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
| “Candida cylindracea” OR “Debaryomyces hansenii” OR “Candida famata” OR “Hanseniaspora uvarum” OR “Kloeckera apiculata” OR “Ogataea angusta” OR “Pichia angusta” OR “Saccharomyces bayanus” OR “Saccharomyces pastorianus”OR “Saccharomyces carlsbergensis” OR “Wickerhamomyces anomalus” OR “Hansenula anomala” OR “Pichia anomala” OR “Saccharomyces anomalus” OR “Candida pelliculosa” OR “Xanthophyllomyces dendrorhous” OR “Phaffia rhodozyma” OR “C cylindracea” OR “D hansenii” OR “C famata” OR “H uvarum” OR “K apiculata” OR “O angusta” OR “P angusta” OR “S bayanus” OR “S pastorianus” OR “S carlsbergensis” OR “W anomalus” OR “H anomala” OR “P anomala” OR “S anomalus” OR “C pelliculosa” OR “X dendrorhous” OR “P rhodozyma” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk |
|
|
| |
|---|---|
|
“Kluyveromyces lactis” OR “Candida spherica” OR “Kluyveromyces marxianus” OR “Candida kefyr” OR “Komagataella pastoris” OR “Pichia pastoris” OR “Lindnerajadinii” OR “Pichia jadinii” OR “Hansenula jadinii” OR “Torulopsis utilis” OR “Candida utilis” OR “Schizosaccharomyces pombe” OR “K lactis” OR “C spherica” OR “K marxianus” OR “C kefyr” OR “K pastoris” OR “P pastoris” OR “L jadinii” OR “P jadinii” OR “H jadinii” OR “T utilis” OR “C utilis” OR “S pombe” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antimycotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “fungemia” OR “fungaemia” OR “mycos*” |
| 3. Type of disease |
|
| 4. Mortality/Morbidity |
|
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Saccharomyces cerevisiae” OR “Saccharomyces boulardii” OR “S cerevisiae” OR “S boulardii” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic | “antimicrobial resistan*” OR “antimycotic resistan*” OR “antimicrobial susceptibil*” |
| 2. Infection/Bacteremia/Fungemia/Sepsis | “infection*” OR “abscess*” OR “sepsis*” or “septic*” OR “fungemia” OR “fungaemia” OR “mycos*” |
| 3. Type of disease |
|
| 4. Mortality/Morbidity | “clinical*” OR “death*” OR “morbidit*” “OR mortalit*” OR “disease*” OR “illness*” |
| 5. Disease Risk | “opportunistic” OR “virulen*” |
|
| |
|---|---|
| “Alphaflexiviridae” OR “Potyviridae” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis | “necros*” |
| 3. Type of disease |
|
| 4. Mortality/Morbidity | “mortalit*” OR “safety concern*” OR “health hazard” |
| 5. Disease Risk | “virulen*” |
|
| |
|---|---|
| “Nuclear polyhedrosis virus” OR “granulovirus” OR “Baculoviridae” | |
|
|
|
| 1. Antimicrobial/Antibiotic/Antimycotic |
|
| 2. Infection/Bacteremia/Fungemia/Sepsis |
|
| 3. Type of disease | “nuclear polyhedrosis” OR “granulosis” |
| 4.Mortality/Morbidity | “mortalit*” OR “safety concern*” OR “health hazard” |
| 5. Disease Risk |
|
| EFSA risk assessment area | Microorganism species/strain | Intended use | EFSA question number | Additional information provided by the EFSA Scientific Unit | Previous QPS status? | To be evaluated? yes or no |
|---|---|---|---|---|---|---|
|
| ||||||
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00722 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2018‐00060 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00746 | Yes | No | |
| Plant protection products |
| Plant protection product | EFSA‐Q‐2017‐00824 | Pesticide risk assessment and peer review of | Yes | No |
| Plant protection products |
| Plant protection product | EFSA‐Q‐2017‐00267 | Request for EFSA to finalise the reporting table on confirmatory data concerning the risk assessment of | Yes | No |
| Feed additives |
| Production of xylanase | EFSA‐Q‐2017‐00749 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00716 | Yes | No | |
| Feed additives |
| Technological additive | EFSA‐Q‐2017‐00745 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00746 | Yes | No | |
| Feed additives |
| Technological additive | EFSA‐Q‐2017‐00744 | Yes | No | |
| Feed additives |
| Production of xylanase | EFSA‐Q‐2018‐00253 | Yes | No | |
| Feed additives |
| Production of threonine | EFSA‐Q‐2018‐00084 | Yes | No | |
| Feed additives |
| Production of lysine | EFSA‐Q‐2018‐00266 | Yes | No | |
| Feed additives |
| Production of histidine | EFSA‐Q‐2018‐00438 | Yes | No | |
| Food additives, food enzymes, flavourings |
| Production of food enzyme | EFSA‐Q‐2018‐00115 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00693 | No | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00756 | Yes | No | |
| Feed additives |
| Technological additive | EFSA‐Q‐2017‐00754 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00755 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2018‐00268 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2018‐00268 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00756 | Yes | No | |
| Feed additives |
| Technological additive | EFSA‐Q‐2017‐00754 | Yes | No | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2017‐00755 | Yes | No | |
| Feed additives |
| Production of mannanase | EFSA‐Q‐2018‐00050 | No | Yes | |
| Feed additives |
| Production of carotenoid | EFSA‐Q‐2017‐00694 | No | Yes | |
| Feed additives |
| Zootechnical additive | EFSA‐Q‐2018‐00268 | Yes | No | |
| Plant protection products |
| Plant protection product | EFSA‐Q‐2017‐00267 | Request for EFSA to finalise the reporting table on confirmatory data concerning the risk assessment of | No | No |
| Feed additives |
| Production of salinomycin sodium (coccidiostat) | EFSA‐Q‐2017‐00661 | No | No | |
| Food additives, food enzymes, flavourings |
| Production of food enzyme transglutaminase | EFSA‐Q‐2017‐00615 | No | No | |
|
| ||||||
| Feed additives | 3sent1, 8sent65, 8sent1748 & 5sent1 | Zootechnical additive | EFSA‐Q‐2017‐00724 | No | No | |
|
| ||||||
| Plant protection products |
| Plant protection product | EFSA‐Q‐2015‐00021 | Request for an EFSA peer review (EFSA Conclusion) on the active substance | No | No |
| Feed additives |
| Production of glucanase | EFSA‐Q‐2017‐00651 | No | No | |
| Feed additives |
| Production of beta‐glucanase, endo‐1,4‐beta‐xylanase and alpha‐amylase | EFSA‐Q‐2018‐00001 | No | No | |
| Food additives, food enzymes, flavourings |
| Production of food enzyme glucoamylase | EFSA‐Q‐2018‐00265 | No | No | |
| Feed additives |
| Production of alpha‐galactosidase | EFSA‐Q‐2017‐00837 | No | No | |
| Plant protection products |
| Plant protection product | EFSA‐Q‐2017‐00593 | Pesticide risk assessment and peer review of | No | No |
| Plant protection products |
| Plant protection product | EFSA‐Q‐2017‐00055 | Request for an EFSA peer review (EFSA Conclusion) on the active substance | No | No |
| Feed additives |
| Production of xylanase | EFSA‐Q‐2017‐00747 | No | No | |
| Feed additives |
| Production of glucanase, alpha‐amylase and protease | EFSA‐Q‐2017‐00717 | No | No | |
| Feed additives |
| Production of xylanase | EFSA‐Q‐2017‐00682 | No | No | |
|
| ||||||
| Feed additives |
| Production of phytase | EFSA‐Q‐2017‐00650 | Yes | No | |
| Food additives, food enzymes, flavourings |
| Production of food additives steviol glycosides (E 960) | EFSA‐Q‐2018‐00242 | GMM strain | Yes | No |
| Novel foods |
| As a novel food (NF) | EFSA‐Q‐2018‐00223 | Request for a scientific opinion on | No | Yes |
|
| ||||||
| Plant protection products |
| Plant protection product | EFSA‐Q‐2015‐00483 | Review of MRLs (Maximum Residue Limits) | Yes | No |
To find more details on specific applications please access the EFSA website ‐ Register of Questions: http://registerofquestions.efsa.europa.eu/roqFrontend/ListOfQuestionsNoLogin?0%26panel=ALL
Where no link is given this means that the risk assessment has not yet been published.
Included in the QPS list as adopted in December 2016 (EFSA BIOHAZ Panel, 2017) and respective updates which include new additions (latest: EFSA BIOHAZ Panel, 2018).
In the current Panel Statement.