Literature DB >> 3262514

Measurement of human blood brain barrier integrity using 11C-inulin and positron emission tomography.

T Hara1, M Iio, T Tsukiyama, F Yokoi.   

Abstract

Positron emission tomography (PET) using 11C-inulin was demonstrated to be applicable to the clinical measurement of blood brain barrier permeability and cerebral interstitial fluid volume. Kinetic data were analyzed by application of a two compartment model, in which blood plasma and interstitial fluid spaces constitute the compartments. The blood activity contribution was subtracted from the PET count with the aid of the 11CO inhalation technique. The values we estimated in a human brain were in agreement with the reported values obtained for animal brains by the use of 14C-inulin.

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Year:  1988        PMID： 3262514     DOI： 10.1007/bf00257322

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  11 in total

1.  Validation of tomographic measurement of cerebral blood volume with C-11-labeled carboxyhemoglobin.

Authors:  M E Phelps; S C Huang; E J Hoffman; D E Kuhl
Journal:  J Nucl Med       Date:  1979-04       Impact factor: 10.057

2.  The radioisotopic assessment of regional microvascular permeability to macromolecules.

Authors:  R Studer; J Potchen
Journal:  Microvasc Res       Date:  1971-01       Impact factor: 3.514

3.  Lower limits of cerebrovascular permeability to nonelectrolytes in the conscious rat.

Authors:  K Ohno; K D Pettigrew; S I Rapoport
Journal:  Am J Physiol       Date:  1978-09

4.  Examination of blood-brain barrier permeability in dementia of the Alzheimer type with [68Ga]EDTA and positron emission tomography.

Authors:  N L Schlageter; R E Carson; S I Rapoport
Journal:  J Cereb Blood Flow Metab       Date:  1987-02       Impact factor: 6.200

5.  Synthesis of 11C-methylated inulin as a radiopharmaceutical for imaging brain edema and pulmonary edema.

Authors:  T Hara; M Iio; K Inagaki
Journal:  Eur J Nucl Med       Date:  1988

6.  Measurement of blood-brain barrier permeability with positron emission tomography and [68Ga]EDTA.

Authors:  R M Kessler; J C Goble; J H Bird; M E Girton; J L Doppman; S I Rapoport; J A Barranger
Journal:  J Cereb Blood Flow Metab       Date:  1984-09       Impact factor: 6.200

7.  A kinetic evaluation of blood-brain barrier permeability in human brain tumors with [68Ga]EDTA and positron computed tomography.

Authors:  R A Hawkins; M E Phelps; S C Huang; J A Wapenski; P D Grimm; R G Parker; G Juillard; P Greenberg
Journal:  J Cereb Blood Flow Metab       Date:  1984-12       Impact factor: 6.200

8.  Intravenous chelated gadolinium as a contrast agent in NMR imaging of cerebral tumours.

Authors:  D H Carr; J Brown; G M Bydder; H J Weinmann; U Speck; D J Thomas; I R Young
Journal:  Lancet       Date:  1984-03-03       Impact factor: 79.321

9.  Osmotic blood-brain barrier modification: clinical documentation by enhanced CT scanning and/or radionuclide brain scanning.

Authors:  E A Neuwelt; H D Specht; J Howieson; J E Haines; M J Bennett; S A Hill; E P Frenkel
Journal:  AJR Am J Roentgenol       Date:  1983-10       Impact factor: 3.959

10.  Evaluation of blood-brain barrier permeability changes in rhesus monkeys and man using 82Rb and positron emission tomography.

Authors:  C K Yen; T F Budinger
Journal:  J Comput Assist Tomogr       Date:  1981-12       Impact factor: 1.826
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